Prospective study of gut hormone and metabolic changes after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass.

PloS One
Rachel ArakawaJudith Korner

Abstract

Laparoscopic sleeve gastrectomy (SG) has surpassed Roux-en-Y gastric bypass (RYGB) as the most prevalent bariatric procedure worldwide. While RYGB and SG demonstrate equivalent short-term weight loss, long-term weight loss tends to be greater after RYGB. Differences in the effect of these procedures on gastrointestinal hormones that regulate energy homeostasis are felt to partially underlie differences in outcomes. The objective of this study was to prospectively quantify blood levels of gut hormones of energy and glucose homeostasis at one year follow up to delineate possible reasons for greater efficacy of RYGB over SG in achieving weight loss. Patients undergoing SG (n = 19) and RYGB (n = 40) were studied before surgery and at 2,12, 26, and 52 weeks postoperatively. Blood samples drawn in the fasted state and after a liquid mixed meal were assayed at baseline, 26, and 52 weeks for peptide YY (PYY), glucagon-like peptide-1 (GLP-1), ghrelin, insulin, glucose, and leptin. Fasting and postprandial appetitive sensations were assessed by visual analog scale. At 1 year there was greater weight loss in RYGB compared with SG patients (30% vs 27%; P = 0.03). Area under the curve (AUC) after the mixed meal for PYY was greater in RYGB p...Continue Reading

References

Feb 1, 1992·The American Journal of Clinical Nutrition·L V Sjöström
Mar 7, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FlintA Astrup
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
May 6, 2003·Gastroenterology·David E Cummings, Karen E Foster
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Kimberly A BrownleySheila G West
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niels VrangPhilip Just Larsen
Aug 24, 2006·The New England Journal of Medicine·Kenneth F AdamsMichael F Leitzmann
Oct 11, 2007·Obesity·Maria Rosario G Araneta, Elizabeth Barrett-Connor
Oct 16, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Judith KornerJens Juul Holst
Jan 3, 2008·Clinical Endocrinology·R P Vincent, C W le Roux
Jun 7, 2008·Obesity Surgery·Ronit T YehoshuaMoshe Rubin
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L Sjöström
May 7, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J KornerM Bessler
Feb 6, 2010·Trends in Endocrinology and Metabolism : TEM·Efthimia KarraRachel L Batterham
Apr 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William R Scott, Rachel L Batterham
Aug 11, 2011·Physiology & Behavior·M BueterC W le Roux
Mar 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anthony Sclafani, Karen Ackroff
Oct 26, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M B MumphreyH-R Berthoud
Nov 20, 2012·Annals of Surgery·John MelissasNikolaos Karkavitsas
Aug 29, 2014·BMJ : British Medical Journal·David E Arterburn, Anita P Courcoulas
Apr 4, 2015·Obesity Surgery·L AngrisaniN Scopinaro
Jun 5, 2015·Molecular Metabolism·T D MüllerM H Tschöp
Dec 24, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Leandro Soriano-GuillénCarmen Garcés
May 26, 2016·Diabetes Care·Rachel L Batterham, David E Cummings
Jun 9, 2016·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Jun 24, 2016·Obesity Surgery·Emmanuel DisseMaud Robert
Oct 11, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Saeed Shoar, Alan A Saber
Feb 16, 2017·The New England Journal of Medicine·Philip R SchauerUNKNOWN STAMPEDE Investigators
Apr 14, 2017·Obesity Surgery·L AngrisaniN Scopinaro
May 8, 2018·Journal of Endocrinological Investigation·A Pucci, R L Batterham
Sep 28, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yukitoshi SakaoHideo Yasuda

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Citations

Jan 5, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Ryan A LaffertyNigel Irwin
Mar 4, 2021·Nutrients·Dimitris Papamargaritis, Carel W le Roux
Jul 25, 2021·International Journal of Molecular Sciences·Liya Kerem, Elizabeth A Lawson

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Methods Mentioned

BETA
gastric bypass
ELISA

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