Prospective study of hippocampal volume and function in human subjects treated with corticosteroids

European Psychiatry : the Journal of the Association of European Psychiatrists
Tomás HájekCyril Höschl

Abstract

Decreased hippocampal volume reported in neuropsychiatric and endocrine disorders is considered a result of putative neuronal damage mediated by corticosteroids. This is the first prospective study of hippocampal volume and function in patients treated with corticosteroids. 14 subjects treated systemically with prednisone or betamethasone for dermatological or rheumatic disorders underwent prospective neurocognitive testing (Auditory Verbal Learning Test-AVLT, Trail Making Test-TMT, Digit Span-DS) and nine of them also repeated magnetic resonance volumetry. The mean duration of treatment between the first and the second assessment was 73+/- 38 days with mean daily dose of 37+/- 17 mg prednisone and 193+/- 29 days, with mean daily dose of 24+/- 15 mg prednisone between the first and the third assessment. There was a trend towards decreases in total AVLT scores and an improvement in the TMT and DS, but no significant changes in the volumes of the right or the left hippocampi between the assessments. Prednisone dose did not correlate with the hippocampal volume change. We observed a trend for decline in verbal memory despite improvement in psychomotor speed, attention/working memory and no macroscopic hippocampal volume changes du...Continue Reading

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Citations

Nov 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Sherwood BrownI Julian Osuji
Feb 13, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sara PolettiFrancesco Benedetti
Jun 3, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sara K DamstedPeter Uldall
Sep 4, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·E Sherwood BrownMary Ellen Bret
Nov 13, 2009·Annals of the New York Academy of Sciences·E Sherwood Brown
Oct 13, 2006·Journal of Affective Disorders·E Sherwood BrownBrandy Johnson
May 28, 2019·Neuropsychology Review·Catherine E Prado, Simon F Crowe
Sep 19, 2021·The Journal of Allergy and Clinical Immunology·Melissa A RosenkranzWilliam W Busse

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