Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United States

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Anala GossaiMargaret R Karagas

Abstract

Merkel cell polyomavirus (PyV) is causally related to Merkel cell carcinoma, a rare skin malignancy. Little is known about the serostability of other PyVs over time or associations with cutaneous squamous cell carcinoma (SCC). As part of a U.S. nested case-control study, antibody response against the PyV VP1 capsid proteins of BK and John Cunningham virus (JC) was measured using multiplex serology on 113 SCC cases and 229 gender, age, and study center-matched controls who had a prior keratinocyte cancer. Repeated serum samples from controls and both pre and postdiagnosis samples from a subset of SCC cases were also tested. Odds ratios (OR) for SCC associated with seropositivity to each PyV type were estimated using conditional logistic regression. Among controls, BK and JC seroreactivity was stable over time, with intraclass correlation coefficients of 0.86 for BK and 0.94 for JC. Among cases, there was little evidence of seroconversion following SCC diagnosis. JC seropositivity prior to diagnosis was associated with an elevated risk of SCC (OR = 2.54; 95% CI, 1.23-5.25), and SCC risk increased with increasing quartiles of JC (Ptrend = 0.004) and BK (Ptrend = 0.02) seroreactivity. PyV antibody levels were stable over time and f...Continue Reading

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W S WoldM Green
Jan 1, 1992·Journal of the American Academy of Dermatology·R E KwaR L Moy
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E BrashJ Pontén
Dec 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R W FløG Haukenes
Jan 17, 1995·International Journal of Cancer. Journal International Du Cancer·S A BirkelandL Frödin
Jun 11, 1996·International Journal of Cancer. Journal International Du Cancer·P MoniniE Cassai
Aug 1, 1997·Nature Medicine·M CarboneH I Pass
Jul 15, 1998·International Journal of Cancer. Journal International Du Cancer·D R EnglishP L Randell
May 4, 1999·International Journal of Cancer. Journal International Du Cancer·M R KaragasL A Mott
Mar 6, 2002·The Journal of Biological Chemistry·Adam LassakKrzysztof Reiss
Oct 9, 2002·Journal of Virological Methods·Peter SehrMichael Pawlita
May 29, 2003·The Journal of General Virology·Annika StoltJoakim Dillner
Oct 2, 2003·British Journal of Cancer·J AdamiF Granath
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C Bressollette-BodinB M Imbert-Marcille
Sep 20, 2005·The Journal of Infectious Diseases·Raymund R RazonableUNKNOWN PV16000 Study Group
Jan 13, 2006·Journal of Immunological Methods·Tim WaterboerMichael Pawlita
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dana E RollisonKathy J Helzlsouer
Mar 16, 2006·Journal of the National Cancer Institute·Margaret R KaragasMichael Pawlita
Apr 22, 2006·Advances in Experimental Medicine and Biology·Parmjeet RandhawaRon Shapiro
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·Kristina KjaerheimMichael Pawlita
Mar 21, 2007·Virology·Armine DarbinyanKamel Khalili
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Jun 21, 2008·PLoS Pathogens·Kristina M MichaelMichael Pawlita
Sep 2, 2008·Emerging Infectious Diseases·Vincent FoulongneMichel Segondy
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Masahiro ShudaYuan Chang
Nov 11, 2008·Virology·Mengxi JiangMichael J Imperiale
Dec 17, 2008·Virology·James M Pipas
Apr 24, 2009·The Journal of General Virology·Tim WaterboerUNKNOWN EPI-HPV-UV-CA Group
Sep 25, 2009·Journal of the National Cancer Institute·Joseph J CarterDenise A Galloway
Mar 17, 2010·Archives of Dermatology·Howard W RogersBrett M Coldiron
Jul 27, 2010·Human Pathology·Kirsten D MertzWerner Kempf

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Mar 27, 2019·BMC Research Notes·Razieh DowranJamal Sarvari

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