PMID: 9443104Jan 27, 1998Paper

Prospective study of mother-to-infant transmission of hepatitis C virus (HCV) infection. Study Group for Vertical Transmission

Journal of Medical Virology
C MazzaE Cariani

Abstract

Seventy-five women with anti-hepatitis C virus (HCV) antibody were enrolled prospectively during pregnancy or at delivery for study of mother-to-child transmission of HCV. Twenty-three women were coinfected with the human immunodeficiency virus (HIV). Seventy babies were monitored for at least 6 months. HCV infection was diagnosed in six infants (8.6%), four of whom were born to anti-HIV-positive mothers. HCV RNA was first detected between 2 and 6 months, and the genotypes of infected babies matched those of their mothers (type 1: n = 4; type 3: n = 2). Identical master sequences of the hypervariable region (HVR1) were detected in a mother-infant pair. In three babies coinfected with HCV and HIV, anti-HCV disappeared between 2 and 7 months, being persistently negative in two cases monitored for 11 and 26 months. Transmitting mothers did not differ significantly from those who did not transmit the infection with anti-HIV, HCV genotypes, and viral load at delivery, but had lower rate of reactivity to C100 by the recombinant immunoblot assay (RIBA) (P < .01). This prospective study confirms transmission of HCV from anti-HIV-negative mothers (4.4% in this series). Absence of anti-C100 antibodies at delivery is apparently related to...Continue Reading

Citations

Sep 18, 2002·Gut·A H MohsenS Norris
Jul 13, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·P Pradat, C Trépo
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A Roberts, Latifa Yeung
Mar 26, 2009·Journal of Medical Virology·Giuseppe Indolfi, Massimo Resti

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