Prospective study of provocative angiograms to localize functional islet cell tumors of the pancreas

Surgery
M S CohenJ A Norton

Abstract

Controversy exists concerning the use of preoperative imaging studies in patients with islet cell tumors. Since 1993 we have evaluated the use of provocative angiography in patients with insulinoma or Zollinger-Ellison syndrome (ZES). Twelve patients with a working diagnosis of insulinoma (n = 4) or ZES (n = 8) were studied. Of the eight patients with ZES, four were known to have multiple endocrine neoplasia type 1. All patients underwent conventional imaging studies followed by provocative angiography. Angiograms were graded based on the ability to detect tumor and regionalize it within the pancreas. Of the three patients with a working diagnosis of ZES but equivocal results of biochemical studies, none had arteriographic imaging of an islet cell tumor or a positive provocative study result (true negative result). Of the nine patients with documented islet cell tumor, seven (78%) underwent arteriographic imaging of the tumor and eight (89%) had correct regional localization by provocative angiography. Sensitivity and specificity for imaging were 78% and 100%, respectively, and for regional localization 89% and 100%, respectively. Provocative angiography is the localization study of choice for both gastrinoma and insulinoma. Ha...Continue Reading

References

Nov 1, 1990·Annals of Surgery·J A NortonR T Jensen
Aug 1, 1984·World Journal of Surgery·R M ZollingerJ Sparks
Jan 1, 1995·Annual Review of Medicine·J B Meko, J A Norton
Jul 1, 1994·The British Journal of Surgery·J B Meko, J A Norton
Jul 1, 1993·World Journal of Surgery·J L DoppmanJ A Norton
Jul 1, 1993·World Journal of Surgery·C H van EyckS W Lamberts

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Citations

Jun 5, 2007·Cardiovascular and Interventional Radiology·Jeshen H G LauMatthew Matson
Sep 4, 2004·Current Treatment Options in Gastroenterology·James M. McLoughlinJeffrey T. Lamont
Mar 15, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·James E Jackson
Sep 22, 2001·Clinical Imaging·A ChatziioannouL Vlachos
Aug 30, 2003·Surgical Oncology·Gerard M Doherty
May 19, 2000·Annals of Surgery·T C LairmoreG M Doherty
Aug 17, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Chirag Patel, Matthew Matson
May 21, 2003·Journal of Internal Medicine·G M Doherty, N W Thompson
May 11, 2000·Seminars in Surgical Oncology·J E PhayT C Lairmore

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