Prospective Study of Serial 18 F-FDG PET and 18 F-Fluoride PET to Predict Time to Skeletal-Related Events, Time to Progression, and Survival in Patients with Bone-Dominant Metastatic Breast Cancer

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Lanell M PetersonJennifer M Specht

Abstract

Assessing therapy response of breast cancer bone metastases is challenging. In retrospective studies, serial 18F-FDG PET was predictive of time to skeletal-related events (tSRE) and time to progression (TTP). 18F-NaF PET improves bone metastasis detection compared with bone scanning. We prospectively tested 18F-FDG PET and 18F-NaF PET to predict tSRE, TTP, and overall survival (OS) in patients with bone-dominant metastatic breast cancer (MBC). Methods: Patients with bone-dominant MBC were imaged with 18F-FDG PET and 18F-NaF PET before starting new therapy (scan1) and again at a range of times centered around approximately 4 mo later (scan2). Maximum standardized uptake value (SUVmax) and lean body mass adjusted standardized uptake (SULpeak) were recorded for a single index lesion and up to 5 most dominant lesions for each scan. tSRE, TTP, and OS were assessed exclusive of the PET images. Univariate Cox regression was performed to test the association between clinical endpoints and 18F-FDG PET and 18F-NaF PET measures. mPERCIST (Modified PET Response Criteria in Solid Tumors) were also applied. Survival curves for mPERCIST compared response categories of complete response+partial response+stable disease versus progressive diseas...Continue Reading

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Citations

May 6, 2020·Cancer Metastasis Reviews·Pieter A BoonstraAnna K L Reyners
Jul 10, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Angelo Castello, Egesta Lopci
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Jul 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gary A UlanerAudrey Mauguen
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Dec 29, 2020·Physiological Reviews·Philippe ClézardinIngunn Holen
Jun 28, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lanell M PetersonHannah M Linden
Aug 21, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Suzanne C van EsCarolina P Schröder
Apr 5, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gary J R Cook, Vicky Goh

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