Prospective study of serum dihydrotestosterone and subsequent risk of benign prostatic hyperplasia in community dwelling men: the Rancho Bernardo Study

The Journal of Urology
J Kellogg ParsonsElizabeth Barrett-Connor

Abstract

Little is known about midlife serum levels of dihydrotestosterone and other androgens before the onset of clinical benign prostatic hyperplasia in community dwelling older men. We measured sex steroid hormones between 1984 and 1987 in the Rancho Bernardo Study. Between 1992 and 1996 surviving participants were evaluated for benign prostatic hyperplasia at followup clinic visits. Benign prostatic hyperplasia was defined as a history of noncancer prostate surgery or a medical diagnosis of benign prostatic hyperplasia. Regression modeling was used to examine associations of serum hormone measures with benign prostatic hyperplasia. In 340 surviving participants with complete data available and no history of prostate cancer or benign prostatic hyperplasia at baseline mean +/- SD age was 64 +/- 9 years and mean followup was 8.4 +/- 0.8 years. Men who reported benign prostatic hyperplasia during followup were older at baseline than those who did not (p <0.001). Higher baseline serum dihydrotestosterone was associated with an increased risk of benign prostatic hyperplasia. The OR for the second, third and fourth quartiles of dihydrotestosterone was 1.83 (95% CI 0.96-3.47), 1.50 (0.79-2.85) and 2.75 (1.46-5.19), respectively (p trend = ...Continue Reading

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Citations

Oct 16, 2012·Cell Biology and Toxicology·Maria Notara, Aamir Ahmed
Apr 20, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Nishant D Patel, J Kellogg Parsons
Jan 11, 2014·Asian Journal of Andrology·Lori A Cooper, Stephanie T Page
Feb 13, 2013·The Journal of Urology·Mohammad-Ali HaghshenoJan Hammarsten
Mar 31, 2012·European Urology·J Kellogg ParsonsUNKNOWN Urologic Diseases in America Project
Jun 17, 2015·Current Urology Reports·Aaron MooreTobias S Köhler
Jan 5, 2011·Psychoneuroendocrinology·Yori GidronGabriela Berg
May 7, 2014·World Journal of Urology·Markus MargreiterArnulf Ferlitsch
Jul 1, 2016·Clinical Drug Investigation·Michael FosslerMichael Manyak
Jan 14, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Bernice AsieduGeorge A Asare
Apr 25, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Soo Liang Ooi, Sok Cheon Pak
Sep 20, 2017·Endocrine-related Cancer·Gido SnaterseJohannes Hofland
Aug 28, 2020·Frontiers in Oncology·Ann Katrin SauerAndreas M Grabrucker
Apr 9, 2011·Current Bladder Dysfunction Reports·J Kellogg Parsons
Jan 21, 2011·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Chun-Hou LiaoHong-Jeng Yu
Jun 9, 2020·Journal of Korean Medical Science·Goh Eun ChungJoo Sung Kim

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