Prospective study of symptomatic atherothrombotic intracranial stenoses: the GESICA study

Neurology
M MazighiF Woimant

Abstract

Symptomatic intracranial atherothrombotic stenoses (ICAS) are associated with high rates of cerebrovascular ischemic events. To conduct a prospective multicenter study to evaluate the natural history of ICAS and, in those patients refractory to medical treatment, the outcomes associated with intracranial angioplasty. Patients aged 18 to 80 were enrolled with symptoms attributed to a single ICAS of > or =50%. Optimal medical therapy of vascular risk factors and preventive antithrombotic therapy were at the discretion of the local investigator. Patients were eligible for intracranial angioplasty after experiencing recurrent stroke despite medical therapy. Neurologic and ultrasonographic examinations were performed at study inclusion, 3 months after enrollment, and every 6 months of follow-up thereafter, for 36 months. One hundred two patients were included, with a mean age of 63.3 +/- 10.4 years. Intracranial artery stenoses involved the vertebral artery in 22.5%, the basilar artery in 25.5%, the middle cerebral artery in 26.5%, and the internal carotid artery in 25.5%. In 27.4% of the patients, the stenoses had clinical hemodynamic characteristics. During a mean follow-up of 23.4 months, 38.2% of the patients had a cerebrovascul...Continue Reading

Citations

May 23, 2007·Der Nervenarzt·C WeimarH-C Diener
Mar 31, 2010·Neuroradiology·Wiebke KurreJoachim Berkefeld
Mar 10, 2009·Journal of Neurology·Teng-Yeow TanTing-Yao Chen
Jul 11, 2006·Current Atherosclerosis Reports·Mikael Mazighi, Alex Abou-Chebl
May 21, 2011·Current Atherosclerosis Reports·Robert A TaylorScott E Kasner
Mar 17, 2007·Current Cardiology Reports·Tudor G JovinMichael B Horowitz
Mar 26, 2013·Current Treatment Options in Cardiovascular Medicine·Fan Z Caprio, Shyam Prabhakaran
Mar 30, 2013·Current Treatment Options in Cardiovascular Medicine·Thalia S FieldOscar R Benavente
Sep 7, 2013·Lancet·Adnan I Qureshi, Louis R Caplan
Jun 8, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P von Weitzel-MudersbachG Andersen
May 2, 2009·Stroke; a Journal of Cerebral Circulation·Bolanle M FamakinUNKNOWN WASID Trial Investigators
Jun 3, 2011·Neurosurgical Focus·Ananth K VellimanaGregory J Zipfel
Jul 12, 2011·Journal of Neurosurgery·Cathy Sila
Jan 10, 2014·Neurosurgery·Mandy J Binning, Erol Veznedaroglu
Jan 10, 2014·Neurosurgery·Ali AlarajVictor Aletich
Nov 28, 2009·Neurological Research·José E CohenRonen R Leker
Jul 6, 2014·Neurosurgery Clinics of North America·Mohamed S TelebOsama O Zaidat
Aug 21, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessia MattioniStefano Ricci
Jul 21, 2011·Stroke Research and Treatment·Maria KhanAyeesha Kamran Kamal
May 17, 2014·Cell Biochemistry and Biophysics·Lin WangJiafeng Chen
Oct 9, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Hye-Jin KimDong-Wha Kang
Nov 21, 2007·AJNR. American Journal of Neuroradiology·J ValaikieneF Schlachetzki
Mar 12, 2011·AJNR. American Journal of Neuroradiology·C-W TangI-H Lee

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