Abstract
Chronic pulmonary aspergillosis (CPA) is an underdiagnosed and misdiagnosed disease and now increasingly recognised. However, the diagnosis of CPA remains challenging. In this study, we aimed to investigate the diagnostic values of serum Aspergillus-specific IgG, IgA and IgM antibodies in patients with CPA. The prospective study was performed at Chinese People's Liberation Army General Hospital in Beijing, from January 2017 to December 2017. Adult patients with lung lesions presented as cavity, nodule, mass, bronchiectasis or severe fibrotic destruction with at least two lobes in CT imaging were enrolled. One hundred healthy persons were also enrolled as additional controls. The serum levels of Aspergillus-specific IgG, IgA and IgM antibodies and galactomannan (GM) levels were measured simultaneously by plate ELISA kit. A total of 202 patients were enrolled in this study, including 42 CPA patients, 60 non-CPA patients and 100 healthy persons. The most common underlying lung diseases in CPA patients were bronchiectasis (28.6%) and COPD (19.0%). The most common symptoms in the CPA patients were cough (76.2%), sputum (71.4%), and fever (45.2%); chest pain (4.8%) was infrequent. Receiver operating characteristic (ROC) curve analysi...Continue Reading
References
Apr 28, 2001·Journal of Clinical Microbiology·M WeigJ Heesemann
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHelen Sambatakou
Aug 23, 2005·Medical Mycology·W W HopeD W Denning
Apr 3, 2007·Chest·Juliette CamusetJacques Cadranel
Jan 25, 2012·Bulletin of the World Health Organization·David W DenningDonald C Cole
May 3, 2012·American Journal of Respiratory and Critical Care Medicine·Keith C MeyerUNKNOWN American Thoracic Society Committee on BAL in Interstitial Lung Disease
May 10, 2012·Medical Mycology·Koichi IzumikawaShigeru Kohno
Jan 22, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C G BaxterM D Richardson
Feb 9, 2013·American Journal of Respiratory and Critical Care Medicine·Miguel-Angel Martínez-GarcíaMontserrat Bertomeu Valdecillos
May 2, 2013·Respiratory Medicine·Yuta KonoYasuhiro Setoguchi
Jun 22, 2013·Mycoses·Marcin G FraczekMalcolm D Richardson
Nov 14, 2014·Journal of Clinical Microbiology·A OlivaS Ranque
May 17, 2015·Medical Mycology·Iain D PageDavid W Denning
May 31, 2015·Thorax·Pushpa M JairamUNKNOWN PROVIDI Study group
Jul 15, 2015·Japanese Journal of Infectious Diseases·Tsunehiro AndoKazutoshi Shibuya
Dec 19, 2015·The Journal of Infection·Iain D PageDavid W Denning
Dec 25, 2015·The European Respiratory Journal·David W DenningUNKNOWN European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Feb 26, 2016·Chest·Cendrine GodetUNKNOWN ACHROSCAN Study Group
Mar 25, 2016·Journal of Clinical Microbiology·Satoru FujiuchiYoshinobu Ohsaki
Jun 21, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yong-Hua GaoGuo-Jun Zhang
Jul 2, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas F PattersonJohn E Bennett
Aug 20, 2016·BMC Pulmonary Medicine·Eavan G MuldoonDavid W Denning
Dec 3, 2016·Mycoses·Helmut J F SalzerChristoph Lange
Jan 12, 2017·BMJ Open Respiratory Research·Nousheen IqbalJavaid A Khan
Feb 10, 2017·The European Respiratory Journal·David LowesDavid W Denning
Mar 24, 2017·Journal of Clinical Microbiology·Naohisa UrabeSakae Homma
Sep 19, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Stephanie EveraertsWim Janssens
Oct 20, 2017·Medicine·Xiaomeng HouJi Li
Feb 10, 2018·International Journal of Molecular Sciences·Stephanie EveraertsWim Janssens
Sep 8, 2018·The Clinical Respiratory Journal·Yake YaoJianying Zhou
Citations
Jul 16, 2020·Journal of Clinical Medicine·Noeul KangByung Woo Jhun
Feb 18, 2021·Mycoses·Keisuke AnanYosuke Yamamoto
Feb 19, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Cornelia Lass-FlörlMiriam Knoll
May 13, 2021·Respirology Case Reports·Takuya MatsuzakiTakashi Urushibara
Jul 3, 2021·Journal of Fungi·Meng-Rui LeeChong-Jen Yu