Prospective study of the short-term adverse effects of gamma knife radiosurgery

Technology in Cancer Research & Treatment
Samuel T ChaoJohn H Suh

Abstract

Purpose of this study is to determine the types, incidence, and severity of acute complications of intracranial stereotactic radiosurgery (SRS), specifically Gamma Knife (GK). Patients who had never had previous SRS were eligible for this prospective IRB-approved study. The questionnaire used applicable questions from CTCAE v.3.0, the Brief Pain Questionnaire (Short Form), Brief Fatigue Inventory, and the Tinnitus Handicap Inventory. Questionnaires were obtained prior to Gamma Knife (GK), 1 week, 1 month, and 2 months to assess complications. Seventy-six eligible patients (median age of 62 years) had complete data and were analyzed. Diagnoses included: 26 (34%) with brain metastases, 15 (20%) with trigeminal neuralgia, 12 (16%) with schwannoma, 10 (13%) with meningioma, 7 (9%) with arteriovenous malformation, 3 (4%) with pituitary adenoma, and 3 (4%) with other. At 1 week, 24% developed minimal scalp numbness (p =0.0004 baseline compared to 1 week). Only 13% had minimal scalp numbness at 1 month and 2% at 2 months (both p=NS compared to baseline). There was no difference in scalp tingling between baseline and the various time points. Thirteen percent developed pin site pain at 1 week with a median intensity level of 2 out of 10...Continue Reading

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Citations

Sep 3, 2014·Environment International·Jung-Chun HoPeter Wushou Chang
Dec 17, 2014·The Cochrane Database of Systematic Reviews·Dario MuzevicPer Cayé-Thomasen
Apr 8, 2020·Neuro-oncology Practice·Sophie D van der LindenMargriet M Sitskoorn
Mar 15, 2020·Neurosurgical Review·Elizabeth J BussMichael B Sisti
Mar 4, 2020·World Neurosurgery: X·Carolina Venda NovaRicheal Ni Riordain

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