Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients

The Journal of Dermatology
Ying MaLeihong Xiang

Abstract

Acne vulgaris is one of the most common skin diseases in adolescents. In the present study, we aimed to evaluate the effectiveness and safety of topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for the treatment of severe acne in Chinese adolescent patients. Twenty-one Chinese adolescent patients aged 12-18 years with Pillsbury III-IV severe facial acne were treated with three courses of ALA-PDT. A 5% ALA lotion was applied topically for 60 min followed by irradiation with light-emitting diode light at 633 nm with a light intensity of 75-80 mW/cm(2) and a light dose of 90-96 J/cm(2) . Clinical assessment was conducted before and after each treatment, and at each follow-up session. The total effective rates were 85.71%, 90.48%, and 95.23% after the three PDT sessions, and at the 4- and 8-week follow ups, respectively. ALA-PDT is an effective treatment for severe adolescent acne vulgaris, and is associated with mild and reversible side-effects.

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Citations

Sep 26, 2015·International Journal of Molecular Sciences·Miri KimHyun Jeong Park
Apr 20, 2016·Photodiagnosis and Photodynamic Therapy·Uma KeyalXiu Li Wang
Aug 20, 2016·Dermatology and Therapy·Theresa N CanavanBoni E Elewski
Jan 29, 2017·Photodermatology, Photoimmunology & Photomedicine·Neha Kumar, Christine B Warren
Jun 26, 2017·Photodiagnosis and Photodynamic Therapy·Xiang WenMichael R Hamblin
Apr 17, 2019·The Journal of Dermatological Treatment·Wei ZhaoHong-Qing Tian
Apr 26, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Marc Z HandlerDavid J Goldberg
Jan 3, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C SalavastruK Fritz
Aug 11, 2019·International Journal of Molecular Sciences·Sarah Raquel De AnnunzioCarla Raquel Fontana
Mar 10, 2017·American Journal of Clinical Dermatology·Monica BoenMaria M Tsoukas
Jul 22, 2021·American Journal of Clinical Dermatology·Monica K LiJeffrey T S Hsu

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