Prospective study on CVID patients with adverse reactions to intravenous or subcutaneous IgG administration.

Journal of Clinical Immunology
I QuintiMassimo Fiorilli

Abstract

The multicenter prospective study provides information on adverse reactions to intravenous and subcutaneous immunoglobulin treatment in a cohort of 262 patients with common variable immunodeficiency. Severe adverse reactions are a rare but unpredictable event that might occur also in patients who tolerate substitutive intravenous or subcutaneous immunoglobulin therapy for months or years. Subcutaneous therapy has been proved to be a safe option in the 13 patients who had to stop intravenous treatment and who remained out of immunoglobulin replacement for long periods of time. However, severe reactions to subcutaneous therapy occurred at the first or after several subcutaneous immunoglobulin administrations in 2 out of 13 patients. Therefore, patients with previous severe reactions to intravenous immunoglobulin should be considered at particularly high risk for reaction to subcutaneous administration. In these cases, switching from in-hospital administration to home self-administration should be done with extreme care.

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Citations

Aug 7, 2010·Southern Medical Journal·Jason K Lee, Stephen D Betschel
Feb 24, 2015·Frontiers in Immunology·Peter J SpäthIsabella Quinti
Jan 26, 2013·Paediatric Respiratory Reviews·Maria Francesca Patria, Susanna Esposito
Aug 21, 2014·Case Reports in Rheumatology·Cherin PatrickCartry Odile
Sep 23, 2010·Autoimmunity Reviews·Maria Giovanna DanieliArmando Gabrielli
Oct 23, 2008·Immunology and Allergy Clinics of North America·Maria Garcia-LloretTalal A Chatila
Oct 22, 2009·Clinical and Experimental Immunology·C Cunningham-Rundles
Oct 9, 2009·Acta Clinica Belgica·Ph R Roelandt, D Blockmans
Dec 24, 2010·Orvosi hetilap·Vera Gulácsy, László Maródi
May 14, 2019·Clinical and Molecular Allergy : CMA·Antonio PecoraroGiuseppe Spadaro

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