Prospective study to compare endometrial cytology and transvaginal ultrasonography for identification of endometrial malignancies

Gynecologic Oncology
H TsudaN Umesaki

Abstract

We compared transvaginal ultrasonography (TVS) and endometrial cytology by the Endocyte method for endometrial cancer screening. A total of 600 postmenopausal women who hoped for endometrial cancer screening (mean age, 61.1 +/- 8.8 years; range, 44-87 years) underwent TVS, endometrial cytology (Endocyte method), and endometrial histology. The endometrial borders could be visualized by TVS in all women studied. However, cytology could not be performed in 59 women (9.8%) due to cervical stenosis. These 59 women were excluded from further study. Of the 541 remaining women, 38 had pathologic conditions (16 had endometrial cancer and 22 had endometrial hyperplasia). One (6.3%) of the 16 endometrial cancer patients and 10 (45.5%) of the 22 hyperplasia patients were asymptomatic. One hundred thirty-nine (83.7%) of the 166 women with postmenopausal bleeding had no pathological condition. When the cutoff value of endometrial thickness was set at 4 mm for women <5 years since menopause and 3 mm for those > or =5 years since menopause, TVS showed a 97.4% sensitivity, 75.7% specificity, 23.8% positive predictive value, and 99.7% negative predictive value. Thirty-seven of the 38 patients with endometrial disease were detected by TVS. Eight ...Continue Reading

References

Jan 1, 1991·Acta Obstetricia Et Gynecologica Scandinavica·P SmithU Ulmsten
Jul 1, 1990·American Journal of Obstetrics and Gynecology·S R GoldsteinL Nachtigall
Dec 1, 1993·American Journal of Obstetrics and Gynecology·A KurjakM Predanic

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Citations

Jul 31, 1999·British Journal of Obstetrics and Gynaecology·C P Spencer, M I Whitehead
Sep 25, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M C BreijerA Timmermans
Sep 22, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·C RemondiE Piccione
Jan 29, 2014·Cytopathology : Official Journal of the British Society for Clinical Cytology·M FambriniS Guaschino
Aug 17, 2005·Gynecologic and Obstetric Investigation·Hiroshi TsudaChristina A Bandera
Feb 15, 2001·Current Opinion in Obstetrics & Gynecology·H T Lynch, M J Casey
Apr 11, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yada TingthanatikulSawaek Weerakeit
Jun 27, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Iztok Takac
May 20, 2003·Acta Obstetricia Et Gynecologica Scandinavica·M K Oehler, M C P Rees

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