Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
M J O'ConnellA Figueredo

Abstract

This study had two major goals: (1) to assess the effectiveness of a regimen of fluorouracil (5-FU) plus levamisole plus leucovorin as postoperative surgical adjuvant therapy for patients with high-risk colon cancer, and (2) to evaluate 6 months versus 12 months of chemotherapy. Patients with poor-prognosis stage II or III colon cancer were randomly assigned to receive adjuvant chemotherapy with either intensive-course 5-FU and leucovorin combined with levamisole, or a standard regimen of 5-FU plus levamisole. Patients were also randomly assigned to receive either 12 months or 6 months of chemotherapy, which resulted in four treatment groups. Eight hundred ninety-one of 915 patients entered (97.4%) were eligible. The median follow-up duration is 5.1 years for patients still alive. There was a difference among the four treatment groups with respect to patient survival, and a significant duration-by-regimen interaction was observed. Specifically, standard 5-FU plus levamisole was inferior to 5-FU plus leucovorin plus levamisole when treatment was given for 6 months (5-year survival rate, 60% v 70%; P < .01). There was no significant improvement in patient survival when chemotherapy was given for 12 months compared with 6 months. ...Continue Reading

Citations

Sep 28, 1998·Cancer Chemotherapy and Pharmacology·B A ConleyS G Arbuck
Aug 5, 1999·Journal of the National Cancer Institute·K C HallingS N Thibodeau
Nov 17, 2001·Diseases of the Colon and Rectum·G BurdyP Valleur
Apr 23, 2003·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S Rao, D Cunningham
Feb 27, 2003·Internal Medicine Journal·A Haydon
Dec 4, 2003·Seminars in Surgical Oncology·Christopher H Crane, John Skibber
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
Aug 31, 2004·Japanese Journal of Clinical Oncology·Luis F Oñate-OcañaDolores Gallardo-Rincón
Oct 18, 2005·Diseases of the Colon and Rectum·Alain BarrierSandrine Dudoit
Sep 16, 2005·Drugs·Ashita M Waterston, Jim Cassidy
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentAimery De Gramont
Oct 22, 2005·World Journal of Surgery·Geoffrey A PorterPaul J Veugelers
Feb 28, 2006·Investigational New Drugs·Pierpaolo CorrealeGiorgio Giorgi
Apr 21, 2007·Digestive Surgery·Kiyotaka Okuno
May 14, 2009·British Journal of Cancer·I Chau, D Cunningham
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentSteven Gallinger
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Diogo Assed BastosPaulo M Hoff
Dec 8, 2011·Cancer Chemotherapy and Pharmacology·J Lee VillanoLinda R Bressler
Mar 30, 2013·Familial Cancer·N Devaud, S Gallinger
Sep 21, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pramodh Chitral ChandrasingheKemal Ismail Deen
Mar 29, 2018·The New England Journal of Medicine·Richard L Schilsky
Feb 27, 2018·Expert Review of Anticancer Therapy·Monica TangMatthew Burge
Jul 23, 1999·Current Opinion in Oncology·E Van Cutsem, M Peeters
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R PorschenUNKNOWN Arbeitsgemeinschaft Gastrointestinale Onkologie
Sep 14, 2002·Current Gastroenterology Reports·Anne Demols, Jean-Luc Van Laethem
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff A SloanCharles L Loprinzi
Jul 14, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James A MartensonRichard M Goldberg
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndreAimery de Gramont
Sep 30, 2004·Langenbeck's Archives of Surgery·K H LinkL Staib
May 31, 2002·Expert Opinion on Investigational Drugs·Mary F Mulcahy, Al B Benson
Jun 9, 2006·Expert Review of Anticancer Therapy·Wendy KelderJohn T M Plukker
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonDaniel G Haller
Apr 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfred I NeugutDawn L Hershman
Apr 15, 2006·Annals of Surgical Oncology·Thierry AndréAimery de Gramont
Dec 8, 2005·Acta Oncologica·Bengt GlimeliusUNKNOWN Nordic Gastrointestinal Tumour Adjuvant Therapy Group
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnold L PotoskyCharles F Lynch

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