PMID: 11898358Mar 20, 2002Paper

Prospects for developing treatment of uveal melanoma from the position of modern carcinogenesis concepts

Vestnik oftalmologii
V G Likhvantseva

Abstract

Immunohistochemical studies of regulator proteins p53, Bcl-2, Bax, Ki-67, and CD-95L showed that apoptosis suppression, allowing unlimited proliferation of tumor cells, plays an important role in the carcinogenesis of uveal melanoma. This fact dictates the need of including drugs arresting suppression or inducing apoptosis in therapeutic protocols for uveal melanoma. Prognostic significance of p53, Bcl-2, Bax, and CD-95L was demonstrated. Each of the peptides can be used as a prognostic marker.

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