PMID: 6988257Jan 1, 1980Paper

Prospects for large scale production of thermolabile products using anchorage dependent cells

Developments in Biological Standardization
G F MannL M Allison

Abstract

Availability of culture systems for the large scale production of anchorage dependent cells is briefly outlined. Studies on two thermolabile viruses (Measles and Influenza), showing inactivation rates of 0.1 - 0.2 log 10 per hour, clearly demonstrate the need for minimal residence time in the culture system. Logistical considerations indicate that small capacity perfusion culture systems for anchorage dependent cells would give increased recovery of these products and may readily be combined with subsequent processing steps.

Related Concepts

Cell Adhesion
Cell Division Phases
Chick Embryo
Cytological Techniques
Edmonston virus
Myxoviruses
Virus Cultivation

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.