Prospects of HA-based universal influenza vaccine

BioMed Research International
Anwar M Hashem

Abstract

Current influenza vaccines afford substantial protection in humans by inducing strain-specific neutralizing antibodies (Abs). Most of these Abs target highly variable immunodominant epitopes in the globular domain of the viral hemagglutinin (HA). Therefore, current vaccines may not be able to induce heterosubtypic immunity against the divergent influenza subtypes. The identification of broadly neutralizing Abs (BnAbs) against influenza HA using recent technological advancements in antibody libraries, hybridoma, and isolation of single Ab-secreting plasma cells has increased the interest in developing a universal influenza vaccine as it could provide life-long protection. While these BnAbs can serve as a source for passive immunotherapy, their identification represents an important step towards the design of such a universal vaccine. This review describes the recent advances and approaches used in the development of universal influenza vaccine based on highly conserved HA regions identified by BnAbs.

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Citations

Dec 8, 2015·Expert Review of Vaccines·Fang HeJimmy Kwang
Jan 23, 2016·Advanced Pharmaceutical Bulletin·Ali AmeghiNosratollah Zarghami
Jul 10, 2018·Human Vaccines & Immunotherapeutics·Rajeev Rudraraju, Kanta Subbarao
Aug 8, 2020·PloS One·Kamonthip RungrojcharoenkitSukathida Ubol
Jul 18, 2017·Influenza and Other Respiratory Viruses·Xueting QiuJustin Bahl
Feb 16, 2020·Archives of Virology·G Lizbeth Ramírez-SalinasJosé Correa-Basurto
Nov 24, 2020·Journal of Biomolecular Structure & Dynamics·Sergei I BazhanLarisa I Karpenko
Aug 7, 2021·Vaccines·Ericka Kirkpatrick Roubidoux, Stacey Schultz-Cherry

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Methods Mentioned

BETA
phage display
glycosylation

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