Prospects of HIV-1 entry inhibitors as novel therapeutics

Reviews in Medical Virology
Theodore C PiersonStefan Pöhlmann

Abstract

A great deal of progress has been made in understanding the mechanism of human immunodeficiency virus entry into target cells. Landmark discoveries such as the identification of viral coreceptors and the structure of a portion of the viral envelope protein (Env) bound to its receptor provided important insight into how Env mediates fusion of the viral and cellular membranes. This knowledge has been successfully applied to the development of inhibitors that target discrete steps of the entry process. Some of these compounds efficiently block HIV-1 replication in vitro and are currently being evaluated in clinical trials. In this review, we will introduce the challenges of antiviral therapy and highlight the need for novel therapeutics, such as entry inhibitors, to complement current antiviral regimens. The mechanism by which Env mediates HIV-1 entry and the therapeutic potential of small molecule inhibitors of this dynamic process will be discussed in detail.

Citations

Dec 6, 2008·Journal of Molecular Modeling·Alexander Berchanski, Aviva Lapidot
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pamela Bean
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Kimberly K AdkisonStephen C Piscitelli
Nov 1, 2008·Expert Opinion on Drug Discovery·Patrick Dorr, Manos Perros
Jun 1, 2012·Expert Opinion on Drug Discovery·Chie HashimotoHirokazu Tamamura
Aug 27, 2015·Reviews in Medical Virology·Miral FumakiaEmmanuel A Ho
May 13, 2008·Drug Discovery Today·Catherine S Adamson, Eric O Freed
Apr 16, 2008·Biochimica Et Biophysica Acta·Aviva LapidotGadi Borkow
Aug 29, 2006·British Journal of Clinical Pharmacology·Kimberly K AdkisonStephen C Piscitelli
Jul 31, 2010·The European Journal of Neuroscience·Alessia BachisItalo Mocchetti
Sep 27, 2005·Drug Discovery Today·Hugues J-P Ryser, Rudolf Flückiger
Dec 15, 2006·Antiviral Research·Changhua JiSurya Sankuratri
Dec 7, 2005·Antiviral Chemistry & Chemotherapy·Mike Westby, Elna van der Ryst
Aug 22, 2007·Reviews in Medical Virology·P D GriffithsY Shao
Mar 12, 2005·Cell Death and Differentiation·M P MattsonA Nath
Oct 18, 2005·AIDS·Raghavan ChinnaduraiFrank Kirchhoff
Feb 26, 2010·Expert Opinion on Therapeutic Patents·Hanbiao Yang, David M Rotstein
Jun 23, 2019·Protein Science : a Publication of the Protein Society·Gang ChenSachdev S Sidhu
Jan 13, 2005·Molecular Pharmacology·Rym BarboucheEmmanuel Fenouillet
Aug 20, 2019·Current Topics in Medicinal Chemistry·Kenji MaedaHiroaki Takeuchi

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