PMID: 8597773Nov 24, 1995Paper

Prospects of immunotherapy for rheumatoid arthritis

Pharmacy World & Science : PWS
B A t Hart, H G Otten

Abstract

The main challenge in the development of new modalities for the treatment of rheumatoid arthritis is to enhance the specificity while reducing the adverse side-effects of therapeutics. Biotechnology provides a variety of reagents, such as monoclonal antibodies, recombinant cytokines, cytokine antagonists, and small peptides, with the potential to interfere with selected stages of the disease process in a highly specific manner. In addition, several new therapeutic approaches have emerged as a result of extensive research with animal models of disease, including T-cell vaccination and bone marrow transplantation. This article discusses current insights into the pathogenesis of rheumatic diseases, focusing on rheumatoid arthritis. A number of new therapeutic modalities for rheumatoid arthritis, in particular those acting on the immune system, are discussed. Because it is not possible to provide a complete overview of all the developments in the field in limited space, a selection of strategies and modalities which are representative of the broad variety of immunotherapeutic approaches currently used are highlighted.

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Citations

Dec 10, 1999·Immunopharmacology and Immunotoxicology·N IvanovskaM Hristova
Sep 26, 2000·Journal of Cutaneous Medicine and Surgery·G M ShivjiD N Sauder

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