Prostacyclin: a potent antimetastatic agent

Science
K V HonnA Skoff

Abstract

Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor. Inhibitors of prostacyclin synthesis increase metastasis. Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.

References

Sep 1, 1979·Circulation Research·A L Hyman, P J Kadowitz
Nov 1, 1979·Nature·D A Stringfellow, F A Fitzpatrick
Aug 30, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·G J GasicS Niewiarowski
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R H Kramer, G L Nicolson
Jun 29, 1978·Nature·S MoncadaJ R Vane
Apr 13, 1979·Biochemical and Biophysical Research Communications·K V HonnL J Marnett
Jan 11, 1975·Cancer·H C Hoover, A S Ketcham
Nov 1, 1973·British Journal of Cancer·P Hilgard
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·G J GasicS Murphy
Feb 1, 1970·British Journal of Haematology·M C BrainJ V Dacie
Jan 10, 1980·Nature·G Poste, I J Fidler
Nov 1, 1980·Prostaglandins·M A Wynalda, F A Fitzpatrick
Jun 5, 1981·Science·B F SloaneK V Honn

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Citations

Jan 1, 1984·Cancer Metastasis Reviews·G J Gasic
Jan 1, 1983·Cancer Metastasis Reviews·E TsuburaS Sone
Apr 1, 1987·Clinical & Experimental Metastasis·C W StackpoleA L Alterman
Jan 1, 1995·Urological Research·P J Effert, T G Strohmeyer
Dec 1, 1994·Cancer Metastasis Reviews·M R SchneiderK V Honn
Dec 1, 1994·Cancer Metastasis Reviews·K V HonnW Hagmann
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·A L JonesR C Coombes
Jan 1, 1994·Cytotechnology·S I GrammatikosW M Miller
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·I KlapanV Cuk
Nov 1, 1992·Cancer Metastasis Reviews·S G Gordon, M Chelladurai
Nov 1, 1992·Cancer Metastasis Reviews·K V HonnJ D Crissman
Nov 1, 1989·Clinical & Experimental Metastasis·G SavaT Giraldi
Jan 1, 1996·Breast Cancer Research and Treatment·M R SchneiderH Graf
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·I YokoyamaH Takagi
Sep 1, 1983·Prostaglandins·M D Bregman, F L Meyskens
Aug 1, 1983·Prostaglandins, Leukotrienes, and Medicine·J MorleyC Gandolfi
Sep 1, 1984·Prostaglandins, Leukotrienes, and Medicine·F M PetryD H Barkla
Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·James L Mulshine, Fred R Hirsch
Apr 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B Damtew, P J Spagnuolo
Apr 1, 1997·Critical Reviews in Oncology/hematology·T Tanaka
Oct 12, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sabine KajitaRicardo V Lloyd

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