Prostacyclin and blood coagulation

Drugs
S Moncada, J R Vane

Abstract

Prostacyclin is a potent but unstable vasodilator, and inhibitor of platelet aggregation, which is produced by blood vessel walls. Platelet aggregability may be constantly conditioned in vivo by local or circulating prostacyclin. Prostacyclin is important in the maintenance of vascular homeostasis and may be implicated in certain disease states. The use of prostacyclin in antithrombotic therapy appears logical, considering its action in increasing platelet cyclic AMP and reducing aggregation; its potential in antithrombotic therapy is presently being explored.

Citations

Oct 1, 1990·Australian and New Zealand Journal of Medicine·J H VialP R Seville
May 15, 2013·Future Cardiology·Julio D DuarteRoberto F Machado
Dec 14, 2006·Prostaglandins & Other Lipid Mediators·Ying Yu, Colin D Funk
Jul 13, 2012·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Osman Tansel DarcinOrkun Sahsivar
Mar 10, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Matthias Barton
May 2, 2000·Anaesthesia and Intensive Care·P V van HeerdenN M Gibbs
Dec 22, 2020·Journal of Vascular Surgery·Laszlo GöbölösEmin Murat Tuzcu

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