Prostacyclin biosynthesis in activated, stimulated and normal mouse peritoneal cell populations

D A StringfellowJ C McGuire


Nonspecific resistance to infectious and neoplastic disease can be enhanced by administration of "immunomodulators". The levels of enhancement can be monitored by following in vitro function of cells of the lympho-reticuloendothelial system. To gain a better understanding of the physiological and biochemical nature of this enhancement, the metabolism of prostaglandin endoperoxide PGH2 was followed in mouse peritoneal cells (PCs). Homogenates of PCs from normal, unstimulated mice yielded primarily prostacyclin (PGI2) when incubated with PGH2. Homogenates of PCs from mice injected with the immunomodulators C. parvum, levamisole HCl, pyran copolymer, or thioglycollate yielded less PGI2. Reductions ranged from 73% for C. parvum to 32% for levamisole. A statistically significant inverse correlation existed between the level of macrophage "activation" and ability of cellular homogenates to produce prostacyclin. The results suggest that prostacyclin may be involved in modulation of nonspecific resistance.


Jun 13, 1975·Annals of the New York Academy of Sciences·M L KarnovskyA Harper
Feb 1, 1977·Cellular Immunology·P S MorahanE R Kern
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D R Webb, P L Osheroff
Jan 1, 1975·Transplantation·J B Hibbs
Nov 25, 1974·Prostaglandins·J Morley


Jan 1, 1988·Life Sciences·P Dore-DuffyR B Zurier
Jan 1, 1981·Mechanisms of Ageing and Development·M K YoungC H Beatty
Dec 1, 1985·Prostaglandins·J C McGuireD E Tracey
Jul 1, 1986·Prostaglandins, Leukotrienes, and Medicine·D DuvalF Homo-Delarche
Sep 1, 1992·Clinical Immunology and Immunopathology·M A LetyF Homo-Delarche
Jun 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·E KarhumäkiK Krohn
Dec 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·R Ashorn

Related Concepts

Peritoneal Fluid (Body Substance)
Neoplastic Cell Transformation
Lymphocyte Activation
Lymphoid Cells
Prostaglandin Endoperoxides
Prostaglandin-Endoperoxide Synthase

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