PMID: 7034023Dec 1, 1981Paper

Prostacyclin effect on cardiovascular system in man evaluated by echocardiography

Prostaglandins and Medicine
M O TriulziG C Maggi

Abstract

This was an echocardiographic study of the cardiovascular effects of prostacyclin (PGI2) infused intravenously to human volunteers at the rate of 20 ng . kg-1 . min-1 for 10 minutes. The following parameters were recorded in the steady state, at one-minute intervals throughout infusion and the ensuing recovery period: systolic, diastolic, and mean blood pressure (SBP, DBP, MBP); heart rate (HR); left ventricle end-diastolic (EDD) and end-systolic diameter (ESD); stroke volume index (SVI); cardiac index (CI); peripheral vascular resistance (PVR); left ventricle fractional shortening (FS) and ejection fraction (EF). We detected a progressive reduction of MBP without any HR modification. MBP reduction was associated with a reduction of PVR and a parallel rise of CI and SVI. There was also an increase of FS and EF reflecting a reduced ESD. We conclude that PGI2 infused in man at the rate stated above causes hypotension reflecting an arterial vasodilating effect; a lack of heart rate reflex response to afterload reduction (probably a nerve-mediated effect of PGI2); and no venous vasodilation, judging from the absence of any change in end-diastolic diameter.

References

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Nov 1, 1980·Prostaglandins and Medicine·M G ClementG Aguggini

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Citations

Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·M O TriulziG Aguggini

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