Prostacyclin-induced contraction of isolated aortic strips from normal and spontaneously hypertensive rats (SHR)

Prostaglandins
J V Levy

Abstract

Prostacyclin (PGI2) (500-5,000 ng/ml) produced a concentration-dependent increase in contractile tension of isolated thoracic aortic strips (AS) from normotensive (WKY) and spontaneously hypertensive rats (SHR). No significant differences were noted between this response to PGI2 in these two groups. Lower concentrations of PGI2, (10 pg/ml - 100 ng/ml) caused neither contraction nor relaxation of agonist-contracted tissue. PGI2 (500-5,000 ng/ml) did not relax KCl or methoxamine contracted AS. In concentrations above 100 ng/ml, PGI2 caused a further increase in tension in KCl-depolarized preparations. The constrictor effect of PGI2 on AS was attenuated by verapamil pretreatment or removal of extracellular Ca++ from the physiological buffer. This inhibitory effect of Ca++ deficiency on the PGI2 response was significantly greater in AS from SHR compared to WKY tissue. The stable metabolite of PGI2, 6-keto PGF1a, caused a weak constrictor effect (40% of KCl reference contraction) over the concentration range 1,000-5,000 ng/ml. Contraction induced by PGI2 was not prevented by pretreatment with antagonists of adrenergic, histamine, serotonin or cholinergic receptors. The contraction response of the rat AS to PGI2 is similar to that re...Continue Reading

Citations

Jun 8, 1989·European Journal of Pharmacology·C BossallerE Fleck
Jan 25, 1991·European Journal of Pharmacology·G BerkenboomJ Fontaine
Nov 1, 1980·Prostaglandins·M A Wynalda, F A Fitzpatrick
Jan 1, 1981·Progress in Lipid Research·L Levine, I Alam
Aug 17, 2010·Acta Pharmacologica Sinica·Michael Sze-Ka Wong, Paul Michel Vanhoutte
Oct 8, 1999·Journal of Cardiovascular Pharmacology·G BerkenboomJ Fontaine
Jul 27, 2005·Journal of Cardiovascular Pharmacology·Anne OttoGuy Berkenboom
Sep 23, 2008·Journal of Cardiovascular Pharmacology·J F ArgachaG Berkenboom
Apr 28, 2010·Journal of Cardiovascular Pharmacology·Wing Tak WongYu Huang
Apr 19, 2011·Journal of Cardiovascular Pharmacology·Jean-François ArgachaRodrigo Moreno-Reyes
Feb 18, 2009·Acta Physiologica·P M VanhoutteM Feletou
May 1, 1994·The Journal of Pharmacy and Pharmacology·S MarukawaS Hishida
Sep 27, 2008·The Journal of Physiology·Paul M Vanhoutte, Eva H C Tang
Mar 17, 2009·Pharmacology & Therapeutics·Eva H C Tang, Paul M Vanhoutte
Sep 15, 2005·British Journal of Pharmacology·Pascale GluaisMichel Feletou
Mar 30, 2016·European Journal of Pharmacology·Wenhong LuoYingbi Zhou
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P HadházyK Magyar
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eduardo Nava, Silvia Llorens
Oct 25, 2016·The Journal of Pharmacy and Pharmacology·Hariane CôcoAna M de Oliveira
Dec 27, 2015·Acta Physiologica·P M VanhoutteE H C Tang
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pascale GluaisMichel Félétou
Sep 30, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Elodie GomezMichel Félétou
Nov 11, 2018·Pflügers Archiv : European journal of physiology·Yingxue CaoChuan-Ming Hao
Oct 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin LiuYingbi Zhou
Jan 26, 2021·Frontiers in Physiology·Maylla Ronacher SimõesDalton Valentim Vassallo
Aug 17, 2018·Journal of Molecular and Cellular Cardiology·T D PaulaL M Bendhack
Nov 28, 2006·European Journal of Pharmacology·Pascale GluaisMichel Félétou
Aug 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin Liu, Yingbi Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.