PMID: 7030379Dec 1, 1981Paper

Prostacyclin-like, and kallikrein activity of amniotic fluid in pre-eclampsia

British Journal of Obstetrics and Gynaecology
A BodzentaF L Wilcox

Abstract

Amniotic fluid from patients with pre-eclampsia was compared with samples obtained from normotensive controls with respect to the inhibiting effect on platelet aggregation (PGI2-like activity) and activating effect on the plasma kallikrein assay and Russell's viper venom test. After 39 weeks gestation, amniotic fluid from pre-eclamptic patients showed significantly less PGI2-like activity ( p less than 0.01) and significantly lower kallikrein levels (p less than 0.01) than that from normotensive controls. The study suggests that the biosynthesis and release of PGI2-like activity and kallikrein may be impaired in pre-eclampsia. In view of the association of pre-eclampsia with intravascular clotting, the highly significant reduction of PGI2-like activity seems important and appears to warrant a clinical trial of prostacyclin administration in this disorder.

References

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Citations

Dec 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B SpitzJ Vermylen
Jun 1, 1993·British Journal of Clinical Pharmacology·J ShenM S Roberts
Sep 1, 1986·American Journal of Obstetrics and Gynecology·W F O'BrienG R Cohen
Jan 1, 1983·Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy·B SpitzJ Vermylen

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