PMID: 2504995Sep 1, 1989Paper

Prostacyclin mediates splanchnic vascular response to norepinephrine in portal hypertension

The Journal of Surgical Research
J V SitzmannP W Lin

Abstract

Portal hypertension is characterized by increased splanchnic blood flow. This hyperemia may be related to the documented in vitro impaired sympathetic response in portal hypertension. Because prostacyclin (PGI2) has been shown to be elevated in portal hypertensive rabbits, we studied whether PGI2 could mediate the reduced sympathetic response. We measured the change in the superior mesenteric artery resistance (Rsma) to norepinephrine infusion in chronic portal vein ligated (PHT) and normotensive rabbits, in both portal hypertensives and normals following cyclooxygenase blockade with 8 mg/kg indomethacin, and finally in portal hypertensive, cyclooxygenase-blocked rabbits with a constant IV infusion of PGI2 at 200 or 300 ng/kg/min. Dose-response curves were obtained and statistical comparisons were based on the dose of norepinephrine producing 50% of maximal Rsma response (ED50). Portal hypertensive rabbits had significantly higher ED50 (310 +/- 4.1 mg/kg) than normotensive rabbits (150 +/- 4.1 mg/kg, P less than 0.01). Cyclooxygenase blockade resulted in marked reduction of the ED50 in both groups and ablated the difference between normotensive and PHT rabbits (20 +/- 2.4 and 20 +/- 2.8 mg/kg/min, respectively). Prostacyclin in...Continue Reading

Citations

Jan 16, 1995·European Journal of Pharmacology·P A CahillJ V Sitzmann
Aug 23, 2001·Pharmacology & Therapeutics·P W Hadoke
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