PMID: 841106Jan 1, 1977Paper

Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid

Prostaglandins
G J DustingJ R Vane

Abstract

The actions of prostacyclin (PGX) and several other derivatives of arachidonic acid were examined on spiral-strips of bovine coronary artery. The strips were contracted by PGE2 and thromboxane A2. Although PGH2 usually cause a transient contraction followed by a relaxation, a few strips were only contracted whilst others were only relaxed. Prostacyclin invariably relaxed coronary artery strips. Sodium arachidonate usually relaxed the strips but occasionally had no effect. Indomethacin increased the resting tone and abolished or substantially reduced the relaxation induced by sodium arachidonate. 15-hydroperoxy arachidonic acid (15-HPAA), a specific inhibitor of prostacyclin synthetase, also increased the resting tone, abolished the effects of sodium arachidonate and the relaxation component of the PGH2 response, but did not greatly modify the relaxation induced by exogenous prostacyclin. These results strongly suggest that prostacyclin mediates the relaxation induced by arachidonic acid in bovine coronary artery strips. As PGH2 is avidly converted into prostacyclin by the vascular tissue of several species including man, prostacyclin is probably involved in the local regulation of the coronary vascular bed.

References

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jan 1, 1975·Circulation Research·A J BlockJ R Vane
Aug 1, 1975·Canadian Journal of Physiology and Pharmacology·S Kalsner
Aug 1, 1975·Japanese Journal of Pharmacology·N TodaK Sakae
Apr 1, 1973·Prostaglandins·M S MinkesP Needleman
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Nov 1, 1973·European Journal of Pharmacology·M C KossJ Nakano
Jun 22, 1968·Nature·N GilmoreJ H Wyllie
Jan 1, 1967·Acta Physiologica Scandinavica·A GlomsteinD Sinclair

❮ Previous
Next ❯

Citations

Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·L Sterin-BordaA L Gimeno
Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·R J GryglewskiJ Swies
Oct 25, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·H Juan
Jul 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·K SchrörR Krebs
Jan 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·K Schrör, P Rösen
Jan 1, 1981·European Journal of Clinical Pharmacology·G G Neri SerneriA Morettini
Jul 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·M A AlievA K Bekbolotova
Jan 1, 1980·Diabetologia·H E HarrisonM Johnson
Oct 15, 1978·Experientia·R J Gryglewski, K C Nicolaou
Jan 1, 1981·Annals of Biomedical Engineering·M M KrauszH B Hechtman
Jul 17, 2010·Pflügers Archiv : European journal of physiology·Matthias Barton
Jul 20, 1983·The American Journal of Cardiology·G J DustingT J Martin
Sep 22, 1980·Brain Research·J PickardW Fitch
Oct 1, 1977·European Journal of Pharmacology·G J DustingJ R Vane
Mar 1, 1979·European Journal of Pharmacology·K M MullaneJ R Vane
Aug 22, 1980·European Journal of Pharmacology·H H WangK E Eakins
Aug 22, 1980·European Journal of Pharmacology·M A WassermanG L Degraaf
May 30, 1980·European Journal of Pharmacology·L SomovaW Förster
Sep 5, 1980·European Journal of Pharmacology·K M Mullane, S Moncada
Mar 12, 1981·European Journal of Pharmacology·G J DustingR D Nolan
Jul 1, 1980·Journal of Molecular and Cellular Cardiology·G G AhumadaP Needleman
Jul 24, 1978·Life Sciences·H E HarrisonM Johnson
Oct 1, 1982·Neuropharmacology·S B Kandasamy, B A Williams
Oct 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·N ShiromaM Sakanashi
Jun 1, 1977·Prostaglandins·W HsuehP Needleman
Apr 1, 1977·Prostaglandins·S MoncadaP Needleman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.