Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.

The Journal of Biological Chemistry
R MuramatsuT Yamashita

Abstract

Pericytes play pivotal roles in physiological and pathophysiological conditions in the central nervous system. As pericytes prevent vascular leakage, they can halt neuronal damage stemming from a compromised blood-brain barrier. Therefore, pericytes may be a good target for the treatment of neurodegenerative disorders, although evidence is lacking. In this study, we show that prostacyclin attenuates lysophosphatidylcholine (LPC)-mediated vascular dysfunction through pericyte protection in the adult mouse spinal cord. LPC decreased the number of pericytes in an in vitro blood-brain barrier model, and this decrease was prevented by iloprost treatment, a prostacyclin analog. Intrathecal administration of iloprost attenuated vascular barrier disruption after LPC injection in the mouse spinal cord. Furthermore, iloprost treatment diminished demyelination and motor function deficits in mice injected with LPC. These results support the notion that prostacyclin acts on pericytes to maintain vascular barrier integrity.

References

Jul 26, 1988·European Journal of Pharmacology·T TerawakiY Masuda
Jan 19, 1995·The American Journal of Cardiology·J R Vane, R M Botting
Nov 24, 1999·Biochemical and Biophysical Research Communications·Y CuiY Watanabe
Feb 8, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jing QiaoHazel Lum
Jul 10, 2007·Nature Neuroscience·Adan AguirreVittorio Gallo
Sep 8, 2007·Cellular and Molecular Neurobiology·Shinsuke NakagawaMasami Niwa
Dec 30, 2008·Neurochemistry International·Shinsuke NakagawaMasami Niwa
Jun 17, 2010·Nature Reviews. Neurology·Dan ShlosbergAlon Friedman
Oct 15, 2010·Nature·Annika ArmulikChrister Betsholtz
Jul 9, 2011·Science·Christian GöritzJonas Frisén
Oct 28, 2011·Nature Neuroscience·Ethan A WinklerBerislav V Zlokovic
Jan 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gary A Rosenberg
Apr 10, 2012·Microvascular Research·Ulrich TiggesRichard Milner
Jul 14, 2012·The European Respiratory Journal·Anna A BirukovaKonstantin G Birukov
Aug 2, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ethan A WinklerBerislav V Zlokovic
Aug 8, 2012·Biochimica Et Biophysica Acta·Ioanna SevastouVassilis Aidinis
Dec 7, 2013·Nature Medicine·Birgit ObermeierRichard M Ransohoff
Dec 18, 2013·Nature Communications·Abhay P SagareBerislav V Zlokovic
Feb 20, 2014·Frontiers in Cellular Neuroscience·Svitlana Garbuzova-Davis, Paul R Sanberg

❮ Previous
Next ❯

Citations

May 14, 2016·Scientific Reports·Tomohiko OzakiToshihide Yamashita
Jan 17, 2017·Scientific Reports·Ken MatobaToshihide Yamashita
Mar 9, 2019·International Journal of Molecular Sciences·Shi-Hui LawLiang-Yin Ke
May 30, 2019·Medicinal Research Reviews·Fubao HuangJianhua Shen
Jan 23, 2020·Journal of Biochemical and Molecular Toxicology·Siqi JiaXiujuan Zhao
Oct 20, 2019·Cellular and Molecular Life Sciences : CMLS·Charlotte G H M de JongWia Baron
Oct 26, 2018·PloS One·Fodé DiopDorothée Missé
Jul 22, 2019·International Journal of Environmental Research and Public Health·Roger G Biringer
Aug 12, 2018·Acta Neuropathologica·Jinping ChengDavid Attwell
Nov 23, 2016·The Journal of Biological Chemistry·Zhijie LinJun Sun
Aug 22, 2017·The Journal of Clinical Investigation·Mariko KurodaToshihide Yamashita
Jun 15, 2019·International Journal of Environmental Research and Public Health·Syena SarrafpourAlfred Fonteh
Nov 5, 2020·International Journal of Molecular Sciences·Akiko Uyeda, Rieko Muramatsu
Sep 3, 2017·Biochemical and Biophysical Research Communications·Yukiko HanadaShoichi Shimada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.