PMID: 7016168May 1, 1981Paper

Prostacyclin production increases during human parturition

British Journal of Obstetrics and Gynaecology
O YlikorkalaL Viinikka

Abstract

The role of prostacyclin (PGI2) in human parturition was studied by measuring the concentrations of its main metabolite, 6-keto-prostaglandin F1 alpha, before, during and after term labour in the plasma of 9 women and after delivery in umbilical artery and vein plasma. The mean level of 6-keto-PGF1 alpha rose significantly over the course of labour. The mean level was 266 pg/ml before labour, 341 pg/ml in the presence of regular contraction, 387 pg/ml at a cervical dilatation of 5 cm, 386 pg/ml at delivery, and 397 pg/ml at the expulsion of the placenta. The 6-keto-PGF1 alpha concentration dropped to below pre-labour levels of 233 pg/ml within 2 hours of delivery, and this level was maintained for the first four postpartum days. The mean levels of 6-keto-PGF1 alpha in the umbilical artery and vein plasma, 1667 and 1193 pg/ml respectively, were significantly higher than the maternal plasma levels. PGI2 is characterized by its antiaggregatory and vasodilating abilities, so that the rise in PGI2 during labour may play a role in the prevention of intrapartum thromboembolic complications in the maternal and the uteroplacental circulation.

References

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Jan 1, 1979·Prostaglandins·C OminiF Berti
Feb 1, 1977·Biology of Reproduction·G C LigginsA L Schwartz
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Mar 1, 1968·Clinical Obstetrics and Gynecology·F K Beller

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Citations

Jan 1, 1992·Progress in Lipid Research·D F Horrobin
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frank Hertelendy, Tamás Zakár
Jun 1, 1982·Archives of Disease in Childhood·P KääpäO Ylikorkala
Nov 27, 2008·The Journal of Clinical Investigation·Kristina M FetalveroKathleen A Martin
Feb 1, 1985·American Journal of Obstetrics and Gynecology·Y Romem, R Artal
Apr 15, 1984·American Journal of Obstetrics and Gynecology·M BusaccaE Dejana
Mar 1, 1995·American Journal of Obstetrics and Gynecology·H A BremerH C Wallenburg
Oct 1, 1981·British Journal of Obstetrics and Gynaecology·O YlikorkalaL Viinikka
Sep 1, 1986·British Journal of Obstetrics and Gynaecology·O YlikorkalaL Viinikka
Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·O Ylikorkala, L Viinikka
Sep 1, 1993·Circulation·E A Meagher, G A FitzGerald
Mar 1, 1983·British Journal of Obstetrics and Gynaecology·O YlikorkalaL Viinikka

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