PMID: 2107105Apr 1, 1990Paper

Prostacyclin versus thromboxane metabolite excretion: changes in pregnancy and labor

European Journal of Obstetrics, Gynecology, and Reproductive Biology
W A Noort, M J Keirse

Abstract

Urinary TXB2 and 6-keto-PGF1 alpha were measured by high pressure liquid chromatography combined with radioimmunoassay, in order to determine whether or not urinary excretion of 6-keto-PGF1 alpha and TXB2 followed a same pattern in pregnancy and labor. The excretion of 6-keto-PGF1 alpha was higher than that of TXB2 in both non-pregnant and pregnant women, but the ratio between them increased in pregnancy. The urinary excretion of both 6-keto-PGF1 alpha and TXB2 excretion was significantly increased (p less than 0.001) in pregnancy. Labor was associated with a much wider inter-individual variation in the excretion of 6-keto-PGF1 alpha and TXB2 than observed in pregnancy and in non-pregnant women. Also, the ratio between the two compounds varied more in labor than in pregnancy. The data indicate that the urinary levels of these two compounds do not follow a single well-determined pattern in pregnancy and labor.

References

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Citations

May 17, 2003·Prostaglandins & Other Lipid Mediators·Frances Moore, Andrés López Bernal
Dec 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R M van der WeidenM J Keirse
Jun 4, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R M van der WeidenM J Keirse
May 1, 1996·American Journal of Obstetrics and Gynecology·R M van der WeidenM J Keirse
Apr 25, 2003·American Journal of Obstetrics and Gynecology·María Eugenia ChavarríaAlejandro Reyes
Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·H C Wallenburg, H A Bremer
Oct 9, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Ryuhiko IwasakiHisanori Minakami

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