Prostaglandin analogue protects pancreatic B-cells against cyclosporin A toxicity

Experientia
M LöhrG Klöppel

Abstract

Cyclosporin A toxicity on pancreatic B-cells and its prevention by rioprostil, a prostaglandin E1 analogue, were studied in the model of the isolated perfused pancreas of rats treated with both compounds for 8 days. At toxic doses of cyclosporin (10 and 20 mg/kg b.wt), the B-cells showed severe hydropic degeneration of the endoplasmatic reticulum and slight degranulation of the B-cells. Accordingly, the insulin secretion was markedly impaired. Administration of rioprostil ameliorated the insulin secretion significantly, but not the ultrastructural changes. At therapeutic levels of cyclosporin (5 mg/kg b.wt), the hydropic degeneration and the drop in insulin secretion were completely prevented by rioprostil. This observation might have therapeutic implications in the treatment of patients, in particular those undergoing pancreatic transplantation.

References

Jan 1, 1986·Transplantation·H J HahnR Warzock
Dec 1, 1985·Diabetes·J F YaleE B Marliss
Jan 1, 1972·Virchows Archiv. A: Pathology. Pathologische Anatomie·G KlöppelG Freytag
Sep 13, 1984·The New England Journal of Medicine·B D MyersM Perlroth
Jan 1, 1981·Prostaglandins·A TarnawskiB Klimczyk

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Citations

Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Nov 22, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M M Sailaja Devi, U N Das

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