Prostaglandin and progesterone production by bovine luteal cells incubated in the presence or absence of the accessory cells of the corpus luteum and treated with interleukin-1beta, indomethacin and luteinizing hormone

Reproduction, Fertility, and Development
R P Del Vecchio, W D Sutherland

Abstract

This experiment examined production of prostaglandin (PG) F2alpha, PGE2 and progesterone by bovine luteal cells incubated with or without the accessory cells and treated with recombinant bovine interleukin-1beta (10 ng), indomethacin (5 microg) or luteinizing hormone (50 ng). During pretreatment, progesterone production was similar in the luteal and luteal plus accessory cells, being greater in either of these than in accessory cells; PGF2alpha was greatest in luteal plus accessory, intermediate in accessory and lowest in the luteal cells; PGE2 was similar among all cell arrangements. Luteinizing hormone or luteinizing hormone plus indomethacin stimulated progesterone in the luteal and luteal plus accessory cells, this being similar in these two cell arrangements. Interleukin-1beta stimulated PGF2alpha in luteal and luteal plus accessory cells, and tended to elevate PGF2alpha in accessory cells. Interleukin-1beta stimulated PGE2 in all cell arrangements. Indomethacin inhibited the interleukin-1beta-stimulated PGF2alpha and PGE2 release. Indomethacin or indomethacin plus luteinizing hormone inhibited basal PGE2 in luteal and luteal plus accessory cells. These data suggest that progesterone production is not influenced by the pre...Continue Reading

Citations

Feb 3, 2007·Reproductive Biology and Endocrinology : RB&E·Matthew J CannonJoy L Pate
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Matthew J CannonJoy L Pate
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Cristiano BoitiAnna Gobbetti
Feb 3, 2016·Journal of Molecular Endocrinology·Katherine A LeehyJulie H Ostrander
Jan 29, 2021·Animals : an Open Access Journal From MDPI·Massimo ZeraniMargherita Maranesi

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