Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs

Nature Communications
Christophe PellefiguesNicolas Charles

Abstract

In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs. Here, we show a role for prostaglandin D2 (PGD2) in the pathophysiology of SLE. Patients with SLE have increased expression of PGD2 receptors (PTGDR) on blood basophils and increased concentration of PGD2 metabolites in plasma. Through an autocrine mechanism dependent on both PTGDRs, PGD2 induces the externalization of CXCR4 on basophils, both in humans and mice, driving accumulation in secondary lymphoid organs. Although PGD2 can accelerate basophil-dependent disease, antagonizing PTGDRs in mice reduces lupus-like disease in spontaneous and induced mouse models. Our study identifies the PGD2/PTGDR axis as a ready-to-use therapeutic modality in SLE.

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Citations

Apr 23, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicolas CharlesEric Daugas
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Methods Mentioned

BETA
FACS
RNA Assay
flow cytometry
ELISA
blood collection
FCS
Protein Assay

Software Mentioned

GraphPad
IDEAS
Treestar
DIVA
STATA
GraphPad Prism
FlowJo
ImageJ

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