Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes

Biochemical Pharmacology
Naoko KandaShinichi Watanabe

Abstract

The antimicrobial peptide human beta-defensin-3 (hBD-3) is produced by epidermal keratinocytes and protects the skin from infections. This peptide induces the release of a lipid mediator, prostaglandin D(2) from dermal mast cells. Prostaglandin D(2) binds to cell-surface G protein-coupled receptors, D prostanoid receptor, and chemoattractant receptor-homologous molecule expressed on T helper cell type 2 (CRTH2). Both receptors are detected on epidermal keratinocytes. It is reported that prostaglandin D(2) is involved in cutaneous allergy, however, its role in antimicrobial defense is unknown. We examined the in vitro effects of prostaglandin D(2) on hBD-3 production in normal human keratinocytes. Prostaglandin D(2) enhanced hBD-3 secretion and mRNA expression in human keratinocytes. Prostaglandin D(2)-induced hBD-3 production was suppressed by the CRTH2 antagonist ramatroban and by antisense oligonucleotides against c-Jun and c-Fos, components of a transcription factor, activator protein-1 (AP-1). Prostaglandin D(2) enhanced the transcriptional activity and DNA binding of AP-1, expression, phosphorylation, and DNA binding of c-Fos proteins in keratinocytes. Prostaglandin D(2)-induced hBD-3 production, AP-1 activity, and c-Fos e...Continue Reading

References

Apr 1, 1990·Journal of Cellular Biochemistry·E A AllegrettoM Karin
Aug 11, 1995·The Journal of Biological Chemistry·Y BoieM Abramovitz
May 5, 2004·The Journal of Biological Chemistry·Ambra PozziJorge H Capdevila
Nov 3, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Minoru YoshidaOsamu Kozawa
Nov 24, 2004·European Journal of Pharmacology·Iwao AraiShiro Nakaike
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Naoko KandaShinichi Watanabe
Apr 27, 2007·The Journal of Investigative Dermatology·Kevin O KisichDonald Y M Leung
Jun 17, 2008·Endocrinology·Naoko Kanda, Shinichi Watanabe
Jan 8, 2009·Immunology·Meredith M Curtis, Sing Sing Way
Apr 8, 2009·European Journal of Immunology·Naoko KandaShinichi Watanabe
Sep 8, 2009·Journal of Dermatological Science·Takeko IshikawaShinichi Watanabe

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Citations

Nov 6, 2012·Progress in Lipid Research·Alexandra C Kendall, Anna Nicolaou
Nov 20, 2012·Innate Immunity·Ernesto Prado Montes de Oca
Feb 15, 2018·International Journal of Molecular Sciences·Kwan Ho JeongHoon Kang
Aug 27, 2013·Current Opinion in Allergy and Clinical Immunology·Verena KopfnagelThomas Werfel
Oct 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamie J Bernard, Richard L Gallo
Jul 19, 2017·Annual Review of Virology·Mayumi K HollyJason G Smith
Apr 23, 2020·Advances in Wound Care·Carlos Poblete JaraEliana Pereira de Araújo
May 7, 2021·The Journal of Allergy and Clinical Immunology·Saptarshi RoyHydar Ali
Apr 24, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Anna Nicolaou

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