Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ikuko MohriYoshihiro Urade

Abstract

Prostaglandin (PG) D2 is well known as a mediator of inflammation. Hematopoietic PGD synthase (HPGDS) is responsible for the production of PGD2 involved in inflammatory responses. Microglial activation and astrogliosis are commonly observed during neuroinflammation, including that which occurs during demyelination. Using the genetic demyelination mouse twitcher, a model of human Krabbe's disease, we discovered that activated microglia expressed HPGDS and activated astrocytes expressed the DP1 receptor for PGD2 in the brain of these mice. Cultured microglia actively produced PGD2 by the action of HPGDS. Cultured astrocytes expressed two types of PGD2 receptor, DP1 and DP2, and showed enhanced GFAP production after stimulation of either receptor with its respective agonist. These results suggest that PGD2 plays an important role in microglia/astrocyte interaction. We demonstrated that the blockade of the HPGDS/PGD2/DP signaling pathway using HPGDS- or DP1-null twitcher mice, and twitcher mice treated with an HPGDS inhibitor, HQL-79 (4-benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]piperidine), resulted in remarkable suppression of astrogliosis and demyelination, as well as a reduction in twitching and spasticity. Furthermore, we fo...Continue Reading

Citations

Jun 15, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Samir S AyoubChristopher Bolton
May 15, 2012·Cell and Tissue Research·Samuel DavidRubèn López-Vales
Feb 12, 2010·Molecular Neurobiology·Dan ZhangJau-Shyong Hong
Sep 29, 2011·Chemical Reviews·William L SmithPer-Johan Jakobsson
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Takahisa MurataHiroshi Ozaki
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Takahisa MurataHiroshi Ozaki
Sep 30, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Rodney R Dietert, Janice M Dietert
Mar 16, 2012·Journal of Biochemistry·Yuji KadoTsuyoshi Inoue
Jul 20, 2007·Journal of Neuroinflammation·Zhongmin XiangSteven A Reeves
Jul 28, 2009·Journal of Neuroinflammation·Sha-Ron PierreMaria E Figueiredo-Pereira
Sep 11, 2010·Journal of Neuroinflammation·Luokun XieShao-Hua Yang
Mar 10, 2010·Journal of Lipid Research·You-Hai XuGregory A Grabowski
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoichi KondoIan D Duncan
Nov 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wei-Min QuOsamu Hayaishi
Aug 8, 2014·Science Translational Medicine·A Sophie de BoerKevin Eggan
Jul 6, 2014·BMC Complementary and Alternative Medicine·Rejoice MoyoStanley Mukanganyama
Sep 28, 2014·Gene·Adriana Carol Eleonora Graziano, Venera Cardile
Nov 5, 2014·Nature Neuroscience·Amelia TrimarcoCarla Taveggia
Sep 23, 2014·Pediatric Neurology·Yedda Li, Mark S Sands
Mar 24, 2011·Drug Metabolism Reviews·Jack U Flanagan, Mark L Smythe
Dec 28, 2012·Biochimica Et Biophysica Acta·Mithilesh Kumar JhaKyoungho Suk
Oct 26, 2011·Sleep Medicine Reviews·Yoshihiro Urade, Osamu Hayaishi
Apr 11, 2009·The American Journal of Pathology·Ikuko MohriYoshihiro Urade
Apr 29, 2009·Toxicology and Applied Pharmacology·Dan ZhangJau-Shyong Hong
Jan 30, 2007·Journal of Neurochemistry·Akhlaq A FarooquiTahira Farooqui
Sep 3, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brigitte MoniotBrigitte Boizet-Bonhoure
Mar 1, 2011·Journal of Ovarian Research·Andalib FarhatBrigitte Boizet-Bonhoure
Sep 4, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mohammad A RafiDavid A Wenger
Oct 31, 2006·Neuroscience·F MarquesJ A Palha
Apr 20, 2013·Toxicology Letters·Christina SobinRodrigo X Armijos
Dec 18, 2013·Experimental Neurology·Mahesh K KaushikYoshihiro Urade
Jul 14, 2012·Mediators of Inflammation·Myungsoo Joo, Ruxana T Sadikot
Jan 19, 2013·Journal of Receptor and Signal Transduction Research·Yang YangWei Wei
Jul 15, 2015·Nature Communications·Tatsuro NakamuraTakahisa Murata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

The American Journal of Pathology
Ikuko MohriYoshihiro Urade
Proceedings of the National Academy of Sciences of the United States of America
Yoshihiro UradeO Hayaishi
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Elisabeth Hansson, Lars Rönnbäck
© 2022 Meta ULC. All rights reserved