PMID: 41947Nov 1, 1979

Prostaglandin E-2-9-ketoreductase in ovarian tissues

Journal of Reproduction and Fertility
J WatsonK S Dodson

Abstract

The existence of the enzyme prostaglandin E-2-9-ketoreductase which can convert prostaglandin E-2 to prostaglandin F-2 alpha was indicated in experiments with pig and human ovarian tissues in vitro, using radioimmunoassay methods and a superfusion technique. Further studies involving radiotracer techniques demonstrated that the enzyme was localized in the high-speed (105 000 g) supernatant fraction of human, pig and rat luteal tissue and human stromal tissue. The enzyme was shown to be NADPH-dependent and its activity in luteal tissue increased in the order : pig less than human less than rat.

References

Feb 1, 1991·Prostaglandins·J D Brannian, P F Terranova
Aug 1, 1993·Prostaglandins·W J MurdochL A McPherson
Jun 5, 2002·Molecular and Cellular Endocrinology·F J DiazMilo C Wiltbank
Nov 5, 1997·Molecular and Cellular Endocrinology·E AsselinM A Fortier
Nov 14, 2003·Reproductive Biology and Endocrinology : RB&E·Milo C Wiltbank, Joseph S Ottobre
Jun 16, 1986·European Journal of Biochemistry·S Krüger, W Schlegel
Sep 1, 1984·British Journal of Obstetrics and Gynaecology·S M SellersA C Turnbull
Apr 1, 1981·British Journal of Obstetrics and Gynaecology·S K SmithD T Baird
Aug 2, 2008·Reproduction, Fertility, and Development·Rosário P Roberto da CostaGraça Ferreira-Dias
Sep 14, 1999·The American Journal of Physiology·W B CaoP Biancani

Related Concepts

Hydroxyprostaglandin Dehydrogenases
Ovary
NADP
Prostaglandins F
Prostaglandins E

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