PMID: 6977613Mar 1, 1982Paper

Prostaglandin E inhibits the production of human interleukin 2

The Journal of Experimental Medicine
R S Rappaport, G R Dodge

Abstract

Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2.

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Citations

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