Prostaglandin E modulation of the mitogenic response of human T cells. Differential response of T-cell subpopulations

The Journal of Clinical Investigation
J D StoboM E Goldyne

Abstract

Prostaglandins (PG) of the E series, PGE(1) and PGE(2) (PGEs), can induce elevations of intracellular cyclic AMP (cAMP) among thymus-derived (T) lymphocytes (T cells) and inhibit their reactivity. For example, 0.1 muM of PGEs induces a two- to threefold increase of intracellular cAMP among human peripheral blood T cells and a 20-30% suppression of their blastogenic response to phytohemagglutinin. However, this suppression actually represents the net reactivity of T-cell populations demonstrating quite different responses to PGEs. Fractionation of T-enriched populations on a discontinuous density gradient yields a population of high density cells whose phytohemagglutinin-induced blastogenic response is suppressed 60%; a population of intermediate density cells whose response is suppressed 20%; and a population of low density T cells whose response is not suppressed, but is enhanced 20% by both of the PGEs. The diametrically opposite responses of low and high density T cells to the PGEs is not related to any difference in their intrinsic mitogen reactivity nor is it influenced by interactions with other T cells, bone marrow-derived (B) cells, or monocytes. Moreover, the distinct blastogenic response of low and high density T cell...Continue Reading

References

Nov 1, 1977·International Journal of Dermatology·M E Goldyne
Mar 15, 1977·Life Sciences·L M Pelus, H R Strausser
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L M WahlS E Mergenhagen
Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J PénitS Jard
Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
Mar 1, 1978·The Journal of Experimental Medicine·J I Kurland, R Bockman
Jul 29, 1976·Nature·D GordonJ Morley

❮ Previous
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Citations

Jan 1, 1986·Rheumatology International·S J HawkinsP J Maddison
Dec 1, 1994·Cancer Metastasis Reviews·Y KikuchiM Fukushima
Jul 1, 1983·Journal of Clinical Immunology·J L Murray, G M Kollmorgen
Oct 1, 1983·Journal of Clinical Immunology·J S Goodwin, J Ceuppens
Jun 1, 1981·Cellular Immunology·P E BakerA Munck
Jan 1, 1983·Progress in Lipid Research·M I Gurr
Mar 1, 1995·Journal of Reproductive Immunology·S Kern, S Maddocks
Jan 1, 1985·International Journal of Immunopharmacology·A E KingstonJ Ivanyi
Jan 1, 1989·International Journal of Immunopharmacology·M SkinnerJ Marbrook
Jan 1, 1992·International Journal of Immunopharmacology·Y KikuchiM Fukushima
Feb 1, 1993·International Journal of Immunopharmacology·R DaculsiN Gualde
Jul 7, 1999·Fundamental & Clinical Pharmacology·J P Redrobe, M Bourin
Aug 1, 1981·Annals of the Rheumatic Diseases·M F MartinJ D Kirby
Jan 1, 1982·Journal of Immunopharmacology·K R McLeishD Senitzer
Mar 1, 1989·Experimental Lung Research·J I KennedyW E Grizzle
Jan 1, 1987·Experimental Lung Research·J I KennedyW E Grizzle
Jan 1, 1983·Cancer Investigation·R S Bockman
Jan 1, 1989·Kidney International·T M CoffmanP E Klotman
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R B Zurier
Mar 1, 1987·Clinical and Experimental Dermatology·M HuszarJ H Passwell
Dec 1, 1983·Disease-a-month : DM·D R Robinson
Feb 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B C MelnikT Tschung
Jan 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H BlomgrenE Baral
Nov 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·J M WanG L Blackburn

❮ Previous
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