Prostaglandin E potentiates the immunologically stimulated histamine release from human peripheral blood-derived mast cells through EP1/EP3 receptors

Allergy
X S Wang, H Y A Lau

Abstract

Mast cells cultured from human peripheral blood have been widely used to study human mast cell function. Prostanoids are the important regulators of mast cell activity, however, there were no reports about the class of prostanoid receptors expressed on such cultured cells. The present study was to characterize pharmacologically the prostanoid receptors by investigating the effects of prostanoid receptor agonists on the immunoglobulin E (IgE)-mediated histamine release from the cultured mast cells. Mast cells cultured from human progenitor cells in peripheral blood were sensitized with human myeloma IgE, and then challenged with anti-human IgE following pretreatment with diverse prostanoid receptor agonists. The histamine content in supernatants and cell pellets were measured by histamine auto-analyzer. Of the prostanoid receptor agonists tested, the prostaglandin E2 (PGE2) receptor (EP receptor) agonist PGE2 (10(-7) to 10(-11) M) produced concentration-related potentiation of IgE-mediated histamine release from the cultured mast cells. Sulprostone, an EP1/EP3 agonist, SC-46275, a selective EP3 agonist, and 11-deoxy-PGE1, a selective EP2/EP3/EP4 agonist also caused a significant increase in histamine release induced by anti-IgE....Continue Reading

References

Apr 15, 1989·The Biochemical Journal·W L Smith
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A A IraniL B Schwartz
Jun 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Takei, K Endo
Dec 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A SavageT H Lanthorn
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K GomiJ S Marshall
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E BrightlingA J Wardlaw
Sep 17, 2004·Pharmacology & Therapeutics·Aaron N Hata, Richard M Breyer
Jun 30, 2005·European Journal of Pharmacology·Hideo K TakahashiMasahiro Nishibori

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Citations

Oct 2, 2008·Immunologic Research·Alasdair M GilfillanDean D Metcalfe
Feb 11, 2012·Critical Reviews in Immunology·Alasdair M Gilfillan, Michael A Beaven
Jul 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Charlotte L WellerTimothy J Williams
Sep 12, 2012·European Journal of Pharmacology·Nabil FoudiXavier Norel
Aug 30, 2008·Journal of Ethnopharmacology·Ben Chung Lap ChanHang Yung Alaster Lau
Oct 9, 2007·Immunology Letters·Hye Sun Kuehn, Alasdair M Gilfillan
May 13, 2015·The Journal of Allergy and Clinical Immunology·Jesper SäfholmMikael Adner
May 21, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroichi Nagai
Jul 20, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sailesh PalikheHae-Sim Park
Apr 14, 2015·BioMed Research International·Fernando H G TessaroJoilson O Martins
Apr 29, 2014·Molecular Immunology·Rosa TorresFernando de Mora
Jul 20, 2014·Biochimica Et Biophysica Acta·Kohichi KawaharaYukihiko Sugimoto
Nov 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Palanisamy ArulselvanS Suresh Kumar
Dec 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pawel Kalinski
Feb 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jeppe SchjerningPernille B L Hansen
Oct 17, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael MorganIrina Vetter
Mar 28, 2019·Frontiers in Microbiology·Jayashree A Chandrasekharan, Neelam Sharma-Walia
Dec 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazushi MorimotoYukihiko Sugimoto
May 14, 2020·Allergy, Asthma & Immunology Research·Judith PlazaFernando de Mora
Jun 2, 2020·Frontiers in Cell and Developmental Biology·Sérgio Ricardo Teixeira DaltroMilena Botelho Pereira Soares
Feb 13, 2018·Immunological Reviews·Ivana HalovaPetr Draber
Aug 28, 2021·International Journal of Molecular Sciences·Akane WadaMotonobu Nakamura
Aug 24, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao Xiao WuChun-Kwok Wong

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