Prostaglandin E1 and noradrenaline at the neuromuscular junction

British Journal of Pharmacology
B L Ginsborg, G D Hirst

Abstract

The effects of prostaglandin E(1) (PGE(1)) on neuromuscular transmission in the frog nerve-sartorius muscle preparation were studied with intracellular recording techniques. PGE(1) was inactive in all concentrations examined; both spontaneous miniature end-plate potentials and evoked end-plate potentials were unchanged after preparations were bathed in up to 2.2x10(-5)M (8 mug/ml) PGE(1). PGE(1) did not prevent the increase in end-plate potential amplitude which frequently occurred on addition of noradrenaline to the bathing solution.

References

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Citations

Nov 1, 1975·European Journal of Pharmacology·W J HallJ D Sheehan
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T AkasuT Tokimasa
Jul 1, 1976·British Journal of Pharmacology·J GripenbergE M Tolppanen
Apr 11, 2020·Cellular and Molecular Neurobiology·Venera Khuzakhmetova, Ellya Bukharaeva

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