PMID: 7200736May 1, 1982Paper

Prostaglandin E1 as a hypotensive drug during general anaesthesia

F GotoT Fujita


Hypotension induced by prostaglandin E1 (PGE1) infusion (100-150 ng/kg/minute) during halothane anaesthesia to reduce operative blood loss during mastectomy was investigated. PGE1 decreased systolic arterial pressure approximately 34% from pre-administration values. The duration of induced hypotension was about 75 minutes. When the infusion was stopped, blood pressure returned to within 15% of the control with 15 minutes. Heart rate did not change significantly during PGE1 infusion; the pre-ejection period and left ventricular ejection period were shortened. Renal function during the hypotensive period was well maintained. Blood loss during surgery was significantly decreased. These findings suggest that PGE1 can be used safely to control arterial pressure during surgery.


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Jan 1, 1993·European Journal of Clinical Pharmacology·K AbeT Sakakibara
Jul 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H YamaguchiH Naito
Nov 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K TakakuraY Goto
Nov 18, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y KadoiN Fujita
Jul 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K NishinaH Obara
Jan 2, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T Nishiyama, K Hanaoka
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masayuki OzakiTakeyoshi Sata
Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K AbeI Yoshiya
Aug 8, 2007·Journal of Anesthesia·Yayoi OhashiTakeshi Tateda
Oct 1, 1990·Journal of Anesthesia·S NakanoH Takano
Jul 1, 1992·Journal of Anesthesia·S KashimotoT Yamaguchi
Oct 1, 1993·Journal of Anesthesia·H KatohM Wakamatsu
Feb 7, 1983·Biochimica Et Biophysica Acta·B RosenkranzJ C Frölich
Feb 1, 1996·Journal of Clinical Anesthesia·A L Kovac
Apr 1, 1997·Prostaglandins·R PacherH Sinzinger
Aug 29, 2003·Medical Hypotheses·K UchidaS Takagi
Aug 11, 2001·Journal of Clinical Anesthesia·H FukudaO Yuge
May 29, 1998·Journal of Clinical Anesthesia·M FukusakiK Sumikawa
Aug 14, 1998·Journal of Clinical Anesthesia·A FuruyaT Kumazawa
Dec 12, 2001·Acta Anaesthesiologica Scandinavica·M MiyabeH Toyooka
May 1, 1994·Acta Anaesthesiologica Scandinavica·M YamakageA Namiki
May 31, 2008·International Journal of Oral and Maxillofacial Surgery·W S Choi, N Samman
Nov 5, 1998·Journal of Cardiothoracic and Vascular Anesthesia·S Aronson, R Blumenthal
Aug 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K AbeI Yoshiya
Nov 1, 1990·Journal of Clinical Anesthesia·K MikawaH Obara
Jul 1, 1993·Journal of Clinical Anesthesia·H YukiokaA Shimazu

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