PMID: 6538584Apr 1, 1984Paper

Prostaglandin E1 coronary venous retroperfusion in acute myocardial ischemia: effects on regional left ventricular function and infarct size

Journal of the American College of Cardiology
M PovzhitkovE Corday

Abstract

Prostaglandin E1 was administered by means of coronary venous synchronized retroperfusion and the effectiveness of the combined (prostaglandin-retroperfusion) system was examined during acute myocardial ischemia in 10 closed chest anesthetized dogs. Such treatment was administered between 30 minutes and 3 hours after occlusion of the proximal left anterior descending coronary artery. An equivalent series of 10 dogs with arterial blood retroperfusion alone and 9 untreated dogs served as control subjects. Standardized two-dimensional echocardiographic measurements of global and regional left ventricular function were performed in five short-axis cross sections. The global low left ventricular section and its profoundly ischemic anterolateral region exhibited distinctly improved systolic fractional area changes as a result of the prostaglandin E1 retroperfusion treatment between 30 minutes and 3 hours after occlusion (22.9 +/- 1.5 to 41.2 +/- 4.0% and 1.8 +/- 3.6 to 29.4 +/- 5.6%, respectively). In contrast, further deterioration in function was noted during an untreated equivalent coronary occlusion period (16.3 +/- 2.7 to 10.0 +/- 3.3% and 12.6 +/- 6.1 to 4.1 +/- 6.9%). Although arterial blood retroperfusion alone provided disti...Continue Reading

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Citations

Feb 1, 1995·The Annals of Thoracic Surgery·H L LazarR J Shemin
Aug 1, 1991·Journal of the American College of Cardiology·S KobayashiE Corday
Jun 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C AuingerH Sinzinger
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·I VirgoliniH Sinzinger
Jul 1, 1991·Journal of the American College of Cardiology·E Corday, R V Haendchen

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