Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions

The Cochrane Database of Systematic Reviews
Smita AkkinapallyMohan Pammi

Abstract

Prostaglandin E1 (PGE1) is used to keep the ductus arteriosus patent and can be life-saving in neonates with ductal-dependent cardiac lesions. PGE1 is used to promote mixing of pulmonary and systemic blood flow or improve pulmonary or systemic circulations, prior to balloon atrial septostomy or surgery. PGE1 therapy may cause several short-term and long-term adverse effects. The efficacy and safety of PGE1 in neonates with ductal-dependent cardiac lesions has not been systematically reviewed. To determine the efficacy and safety of both short-term (< 120 hours) and long-term (≥120 hours) PGE1 therapy in maintaining patency of the ductus arteriosus and decreasing mortality in ductal-dependent cardiac lesions. We searched the literature in October 2017, using the search strategy recommended by Cochrane Neonatal. We searched electronic databases (CENTRAL (in the Cochrane Library), MEDLINE, CINAHL, Embase); abstracts of the Pediatric Academic Societies; websites for registered trials at www.clinicaltrials.gov and www.controlled-trials.com; and in the reference list of identified articles. Randomized or quasi-randomized trials using PGE1 at any dose or duration to maintain ductal patency in term or late preterm (≥ 34 weeks' gestatio...Continue Reading

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Citations

Sep 6, 2019·Journal of Paediatrics and Child Health·Giannina Tinoco MendozaMohamed E Abdel-Latif
Jun 3, 2020·Journal of Cardiac Surgery·Anoop S SumalAhmed M H A M Mostafa
Apr 19, 2019·Journal of Clinical Medicine·Katie L SkeffingtonMassimo Caputo
Sep 20, 2019·International Journal of Molecular Sciences·Daniel Christoph AmbergerHelga Maria Schmetzer
May 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aneta Ostróżka-Cieślik, Barbara Dolińska
May 22, 2021·BMC Pregnancy and Childbirth·Sarah HelandKirsten R Palmer
Oct 1, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marlena E SabatinoNéstor Sandoval
Dec 2, 2019·Neonatology·Verónica Palma-BarquerosFrancisca Ferrer-Marín
Jan 15, 2021·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Daniel Christoph Amberger, Helga Maria Schmetzer

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