PMID: 7201134Jan 1, 1982

Prostaglandin E1 infusion in newborns with hypoplastic left ventricle and aortic atresia

Pediatric Cardiology
A R HastreiterS Levitsky

Abstract

Prostaglandin E1 (PGE1) infusion was used in 7 infants with hypoplastic left ventricle and aortic atresia. Of 5 non-operated patients, 4 died shortly after the onset of PGE1 infusion and 1 survived for 30 hours. Of the infants who had surgery, 1 died during the operation and 1 survived for 38 days. In 6 infants, a transient metabolic and/or circulatory improvement could be demonstrated following PGE1 infusion. The lack of response of other infants may be related to the advanced deterioration of their clinical status at the time of study. In the light of recent surgical developments for infants with aortic atresia, support with PGE1 may nevertheless play an important role in their management if started early.

References

Mar 1, 1984·Journal of the American College of Cardiology·O H TeixeiraP Vlad
Nov 1, 1984·Archives of Disease in Childhood·K A Hallidie-Smith
Dec 1, 1983·American Heart Journal·R L van der HorstF A Eckner
Apr 1, 1991·DICP : the Annals of Pharmacotherapy·M L Buck

Citations

Jan 18, 1975·Lancet·R B ElliottJ M Neutze
Aug 30, 1975·Lancet·N C Christensen, J Fabricus
Sep 1, 1978·The Journal of Pediatrics·A B LewisP R Lurie
Nov 1, 1977·The Journal of Pediatrics·P LangA S Nadas
Mar 1, 1973·Canadian Journal of Physiology and Pharmacology·F Coceani, P M Olley
Jan 1, 1980·The American Journal of Cardiology·W I NorwoodS P Sanders
Jan 1, 1980·Ultrasound in Medicine & Biology·R C Chivers

Related Concepts

Aplastic Anemia
Left Ventricular Structure
Diastolic Blood Pressure
Acidosis, Respiratory
Multiple Congenital Anomalies
Caverject
Descending Aorta
Metabolic Acidosis
Aortic Diseases
Prostaglandins E

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