PMID: 1926911Apr 1, 1991Paper

Prostaglandin E1 treatment of congenital heart disease: use prior to neonatal transport

DICP : the Annals of Pharmacotherapy
M L Buck


Prostaglandin E1 (PGE1) is used to maintain the patency of the ductus arteriosus in neonates when it is necessary to circumvent a defect in the heart or aorta in order to provide adequate peripheral perfusion. It has recently been recommended that medical stabilization with PGE1 be done as soon as a ductus-dependent cardiac defect is suspected, preferably prior to transport of the infant to a tertiary care center for surgical repair of the defect. To accomplish this, hospitals providing obstetric services will need to maintain a supply of PGE1. This commentary provides guidelines for determining the need to stock PGE1 and presents a brief review of the physiology of the ductus arteriosus and the pharmacology and adverse effects of PGE1 therapy.


Dec 1, 1975·The Journal of Clinical Investigation·M GolubR Horton
Feb 1, 1990·Pediatric Clinics of North America·L L Bailey, S R Gundry
Feb 1, 1990·Pediatric Clinics of North America·J I Hoffman
Nov 1, 1986·Journal of the American College of Cardiology·D A DanfordD G McNamara
Nov 1, 1984·Archives of Disease in Childhood·K A Hallidie-Smith
Nov 1, 1982·Drug Intelligence & Clinical Pharmacy·S L Roehl, R J Townsend
Jan 1, 1982·Pediatric Cardiology·A R HastreiterS Levitsky
Nov 1, 1980·The Journal of Pediatrics·K SoneT Kuroume

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