PMID: 8583605Mar 1, 1996Paper

Prostaglandin E1 versus mixture of prostaglandin E1, papaverine and phentolamine in nonresponders to high papaverine plus phentolamine doses

The Journal of Urology
A BecharaN Fredotovich

Abstract

We evaluated the efficacy of 40 micrograms/ml, prostaglandin E1 versus a combination of 17.64 mg./ml. papaverine hydrochloride, 0.58 mg./ml. phentolamine mesylate and 5.8 micrograms/ml. prostaglandin E1 (3-drug mixture). A total of 32 patients randomly received 1 ml. of either medication by the intracavernous route. All patients had presented with erectile dysfunction longer than 6 months in duration and had failed to respond to high doses of papaverine (60 mg.) plus phentolamine (1 mg). Of 32 patients 7 (22%) responded to prostaglandin E1 and 16 (50%) to the 3-drug mixture, achieving erections allowing penetration (grade E4 or E5, p < 0.05). Pain was reported by 41% of the patients receiving prostaglandin E1 and 12.5% administered the 3-drug mixture. The 3-drug mixture may be regarded as more effective than prostaglandin E1 alone in inducing an erectile response with a decreased incidence of pain.

References

Jan 1, 1991·Scandinavian Journal of Urology and Nephrology·P H GraversenH Colstrup

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Citations

Jun 27, 2002·Current Urology Reports·A Nehra
Dec 31, 1997·Urology·P Werthman, J Rajfer
Apr 1, 1997·Trends in Endocrinology and Metabolism : TEM·A M Robinson, R E Ryder
Apr 16, 1998·Journal of General Internal Medicine·M S LitwinN Dhanani
Dec 18, 2013·Journal of Chromatographic Science·Eva KalmárGyörgy Dombi
Mar 6, 2015·Expert Opinion on Emerging Drugs·Taylor C PeakWayne J G Hellstrom
Jan 23, 2010·The Journal of Sexual Medicine·Ian EardleySung Won Lee
Jan 1, 1997·The Diabetes Educator·B A Saulie, R K Campbell
Dec 7, 2018·Expert Opinion on Emerging Drugs·U MilenkovicM Albersen
Jun 1, 1997·The Journal of Urology·K A Hanash

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