PMID: 2118760Aug 15, 1990Paper

Prostaglandin E2 does not regulate total or myofibrillar protein breakdown in incubated skeletal muscle from normal or septic rats

The Biochemical Journal
P O HasselgrenJ E Fischer

Abstract

The role of prostaglandins in the regulation of muscle protein breakdown is controversial. We examined the influence of arachidonic acid (5 microM), prostaglandin E2 (PGE2) (2.8 microM) and the prostaglandin-synthesis inhibitor indomethacin (3 microM) on total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscles incubated under different conditions in vitro. In other experiments, the effects of indomethacin, administered in vivo to septic rats (3 mg/kg, injected subcutaneously twice after induction of sepsis by caecal ligation and puncture) on plasma levels and muscle release of PGE2 and on total and myofibrillar protein breakdown rates were determined. Total and myofibrillar proteolysis was assessed by measuring production by incubated muscles of tyrosine and 3-methylhistidine respectively. Arachidonic acid or PGE2 added during incubation of muscles from normal rats did not affect total or myofibrillar protein degradation under a variety of different conditions in vitro. Indomethacin inhibited muscle PGE2 production by incubated muscles from septic rats, but did not lower proteolytic rates. Administration in vivo of indomethacin did not affect total or myofibrillar muscle protein breakdown, de...Continue Reading

Citations

Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G R KlegerP E Ballmer
Jan 29, 2014·Nature Reviews. Rheumatology·Marina Korotkova, Ingrid E Lundberg
Feb 10, 2006·American Journal of Physiology. Cell Physiology·Brenda A BondesenGrace K Pavlath
Jan 30, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret L NovakTimothy J Koh
May 10, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brenda A BondesenGrace K Pavlath
Jun 1, 1996·The American Journal of Physiology·M G ThompsonG Calder
Mar 30, 2013·Journal of Applied Physiology·Todd A Trappe, Sophia Z Liu
Jun 27, 1997·Biochimica Et Biophysica Acta·X Zhou, J R Thompson

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