Prostaglandin E₂ induced contraction of human intercostal arteries is mediated by the EP₃ receptor

European Journal of Pharmacology
Dan LongroisXavier Norel

Abstract

Arterial vascularization of the spinal cord may be mechanically or functionally altered during thoraco-abdominal surgery/intravascular procedures. Increased arterial pressure has been shown to restore spinal perfusion and function probably by increasing the blood flow through the intercostal arteries. The regulation of human intercostal artery (HICA) vascular tone is not well documented. Prostaglandin (PG)E(2) concentration is increased during inflammatory conditions and has been shown to regulate vascular tone in many preparations. In this context, the pharmacological response of HICA to PGE(2) and the characterization of the PGE(2) receptor subtypes (EP(1), EP(2), EP(3) or EP(4)) involved are of importance and that is the aim of this study. Rings of HICA were prepared from 29 patients and suspended in organ baths for isometric recording of tension. Cumulative concentration-response curves were performed in these preparations with various EP receptor agonists in the absence or presence of different receptor antagonists or inhibitors. PGE(2) induced the contraction of HICA (E(max)=7.28 ± 0.16 g; pEC(50) value=0.79 ± 0.18; n=17); contractions were also observed with the EP(3) receptor agonists, sulprostone, 17-phenyl-PGE(2), mis...Continue Reading

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Citations

Jun 25, 2013·Prostaglandins & Other Lipid Mediators·Gulsev OzenXavier Norel
Jan 18, 2014·Biochemical Pharmacology·Eiron CudabackC Dirk Keene
Feb 13, 2014·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin LiuYingbi Zhou
Oct 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin LiuYingbi Zhou
Aug 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bin Liu, Yingbi Zhou

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