PMID: 9176657Apr 1, 1997Paper

Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome

Acta Odontologica Scandinavica
M Barr-AgholmeT Modéer

Abstract

The levels of prostaglandin E2 (PGE2) and interleukin-1 beta (IL-1 beta) were determined in gingival crevicular fluid (GCF) collected from patients with gingivitis: 15 Down syndrome children and 15 controls. The mean level of PGE2 in GCF was significantly higher (P < 0.05) in the Down syndrome group (10.0 pg/microliters GCF) than in the control group (4.6 pg/microliters GCF). In GCF samples collected from sites characterized as noninflamed, the mean level of PGE2 was significantly higher (P < 0.001) in the Down syndrome group than in the controls. The mean level of PGE2 in samples from inflamed sites, on the other hand, did not differ between the two groups. The mean level of IL-1 beta was not significantly higher in the Down syndrome group than in the controls. This study shows that the level of PGE2 detected in GCF from Down syndrome patients is increased, a fact that may be of importance in the pathogenesis of the periodontal disease frequently seen in these patients.

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Citations

Jun 7, 2003·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Rubén López-PérezGerardo Maupomé
Oct 2, 2001·Journal of Periodontology·P E EngströmG N Engstrom
Nov 5, 2011·Journal of Periodontology·Lícia Bezerra CavalcanteRaquel M Scarel-Caminaga
Apr 17, 2007·Annals of the New York Academy of Sciences·Ira B Lamster, Joseph K Ahlo
Nov 10, 2007·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·James Morgan
May 27, 2010·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Ahmed KhochtBobby Turner
Apr 18, 2014·Periodontology 2000·Ahmed Khocht, Jasim M Albandar
May 18, 2006·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Takanobu MorinushiSachiko Kinjyo
Jan 13, 2001·Periodontology 2000·R I GarciaE A Krall
Jan 12, 2011·Clinical Oral Investigations·Georgios TsilingaridisThomas Modéer
Jan 9, 2021·Prostaglandins & Other Lipid Mediators·John O MarentetteJames R Roede

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