Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1

Virus Research
Megan C ProcarioJason B Weinberg

Abstract

Neonatal mice are more susceptible than adults to mouse adenovirus type 1 (MAV1) respiratory infection. In adult mice, MAV-1 respiratory infection induces production of prostaglandin E2 (PGE2), a lipid mediator that exerts suppressive effects on a variety of host immune functions. We tested the hypothesis that exaggerated PGE2 production in neonatal mice contributes to increased susceptibility to MAV-1. PGE2 concentrations were lower in lungs of uninfected neonatal mice than in adults. PGE2 production was induced by both MAV-1 and a nonspecific stimulus to a greater degree in neonatal mice than in adults, but only in adults was PGE2 induced in a virus-specific manner. Lung viral loads were equivalent in PGE2-deficient neonatal mice and wild type controls, as was virus-induced expression of IFN-γ, IL-17A, and CCL5 in the lungs. PGE2 deficiency had minimal effect on production of virus-specific IgG or establishment of protective immunity in neonatal mice. Collectively, our data indicate that lung PGE2 production is exaggerated early in life, but this effect does not mediate increased susceptibility to MAV-1 infection.

References

Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·E R Fedyk, R P Phipps
Apr 16, 1999·Biochemistry and Molecular Biology International·T ChakrabortiS Chakraborti
Feb 28, 2002·The Journal of Infectious Diseases·Michelle L SeymourAnthony P Sampson
Nov 5, 2002·Immunology Letters·Rachel L RoperRichard P Phipps
May 22, 2003·Paediatric Respiratory Reviews·James E Crowe, John V Williams
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Catherine E TrebinoLaurent P Audoly
Aug 2, 2005·Virology·Jason B WeinbergKatherine R Spindler
Sep 19, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
Jun 23, 2007·American Journal of Respiratory Cell and Molecular Biology·Carlos H SerezaniMarc Peters-Golden
Nov 6, 2007·The New England Journal of Medicine·Marc Peters-Golden, William R Henderson
May 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jie ZhaoHong Tang
Sep 23, 2009·Current Opinion in Pediatrics·Mirjam BelderbosLouis Bont
Dec 25, 2009·The Journal of Infectious Diseases·Patrick C Y WooKwok-Yung Yuen
Feb 16, 2011·Nature Immunology·Mercy PrabhuDasClaire-Anne Siegrist
Apr 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew T Pavia
Dec 7, 2011·Respiratory Research·Megan N BallingerBethany B Moore
Mar 23, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·David MartinoSusan Prescott
Jun 6, 2012·Mediators of Inflammation·Mary K McCarthy, Jason B Weinberg
Oct 17, 2014·Journal of Virology·Mary K McCarthyJason B Weinberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here